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Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase
Wang, Huimei1; Han, Shulan1,2; Wang, Lianyan2; Yang, Tingyuan2; Zhang, Guifeng2; Yu, Lian3; Zhao, Yue4
2018-04-01
发表期刊PARTICUOLOGY
ISSN1674-2001
卷号37页码:64-71
摘要Accumulating evidence suggests that the flavone glycoside baicalin has immunomodulatory effects and antitumor potential. However, its weak stability in solution, poor absorption, and low bioavailability limit its clinical application. To overcome these disadvantages, we developed baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles (PLGA-B) of small size. Next, we evaluated the dual function of immunotherapy and chemotherapy for PLGA-B using immune-related cells and tumor cells. Results showed that PLGA-B were spherical, with a particle size similar to 120 nm and narrow size distribution with an excellent polydispersity index of 0.103. In vitro experiments revealed that baicalin and PLGA-B could activate dendritic cells (DCs) to have higher expression of surface marker molecules and costimulatory molecules than those of control cells. Baicalin and PLGA-B could trigger apoptosis in melanoma (B16) cells via cell-cycle arrest at the G2/M phase. These data suggest that PLGA-B have important roles in activating DCs and killing melanoma cells. Our study could lay a foundation for melanoma treatment through a combined strategy of immunotherapy and chemotherapy. (C) 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
关键词Baicalin Baicalin-loaded Plga Nanoparticles Dendritic Cells Activation Anti-tumor
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1016/j.partic.2017.06.008
收录类别SCI
语种英语
关键词[WOS]IN-VITRO ; LUNG-CANCER ; SCUTELLARIA-BAICALENSIS ; HUMORAL RESPONSES ; DELIVERY SYSTEMS ; APOPTOSIS ; VACCINE ; PLGA ; LIPOSOMES ; EXTRACT
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Chemical ; Materials Science, Multidisciplinary
项目资助者National Science and Technology Major Project of China(2014ZX09102045-008) ; National Science Foundation of China(21476243 ; Fundamental Research Funds for the Central Universities(DL13EA03-03 ; Natural Science Foundation of Heilongjiang Province(C2015051) ; 973 Program(2013CB531500) ; 81274101) ; 2572016EAJ1)
WOS记录号WOS:000425557700009
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24052
专题生化工程国家重点实验室
作者单位1.Northeast Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Jiamusi Univ, Coll Pharm, Jiamusi 154000, Peoples R China
4.NHLBI, Epithelial Syst Biol Lab, Syst Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA
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Wang, Huimei,Han, Shulan,Wang, Lianyan,et al. Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase[J]. PARTICUOLOGY,2018,37:64-71.
APA Wang, Huimei.,Han, Shulan.,Wang, Lianyan.,Yang, Tingyuan.,Zhang, Guifeng.,...&Zhao, Yue.(2018).Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase.PARTICUOLOGY,37,64-71.
MLA Wang, Huimei,et al."Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase".PARTICUOLOGY 37(2018):64-71.
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