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Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase
Wang, Huimei1; Han, Shulan1,2; Wang, Lianyan2; Yang, Tingyuan2; Zhang, Guifeng2; Yu, Lian3; Zhao, Yue4
2018-04-01
Source PublicationPARTICUOLOGY
ISSN1674-2001
Volume37Pages:64-71
AbstractAccumulating evidence suggests that the flavone glycoside baicalin has immunomodulatory effects and antitumor potential. However, its weak stability in solution, poor absorption, and low bioavailability limit its clinical application. To overcome these disadvantages, we developed baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles (PLGA-B) of small size. Next, we evaluated the dual function of immunotherapy and chemotherapy for PLGA-B using immune-related cells and tumor cells. Results showed that PLGA-B were spherical, with a particle size similar to 120 nm and narrow size distribution with an excellent polydispersity index of 0.103. In vitro experiments revealed that baicalin and PLGA-B could activate dendritic cells (DCs) to have higher expression of surface marker molecules and costimulatory molecules than those of control cells. Baicalin and PLGA-B could trigger apoptosis in melanoma (B16) cells via cell-cycle arrest at the G2/M phase. These data suggest that PLGA-B have important roles in activating DCs and killing melanoma cells. Our study could lay a foundation for melanoma treatment through a combined strategy of immunotherapy and chemotherapy. (C) 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
KeywordBaicalin Baicalin-loaded Plga Nanoparticles Dendritic Cells Activation Anti-tumor
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.partic.2017.06.008
Indexed BySCI
Language英语
WOS KeywordIN-VITRO ; LUNG-CANCER ; SCUTELLARIA-BAICALENSIS ; HUMORAL RESPONSES ; DELIVERY SYSTEMS ; APOPTOSIS ; VACCINE ; PLGA ; LIPOSOMES ; EXTRACT
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Chemical ; Materials Science, Multidisciplinary
Funding OrganizationNational Science and Technology Major Project of China(2014ZX09102045-008) ; National Science Foundation of China(21476243 ; Fundamental Research Funds for the Central Universities(DL13EA03-03 ; Natural Science Foundation of Heilongjiang Province(C2015051) ; 973 Program(2013CB531500) ; 81274101) ; 2572016EAJ1)
WOS IDWOS:000425557700009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24052
Collection生化工程国家重点实验室
Affiliation1.Northeast Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Jiamusi Univ, Coll Pharm, Jiamusi 154000, Peoples R China
4.NHLBI, Epithelial Syst Biol Lab, Syst Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Wang, Huimei,Han, Shulan,Wang, Lianyan,et al. Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase[J]. PARTICUOLOGY,2018,37:64-71.
APA Wang, Huimei.,Han, Shulan.,Wang, Lianyan.,Yang, Tingyuan.,Zhang, Guifeng.,...&Zhao, Yue.(2018).Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase.PARTICUOLOGY,37,64-71.
MLA Wang, Huimei,et al."Dual-function baicalin and baicalin-loaded poly(lactic-co-glycolic acid) nanoparticles: Immune activation of dendritic cells and arrest of the melanoma cell cycle at the G2/M phase".PARTICUOLOGY 37(2018):64-71.
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