Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism
Yang, Jierong1,2; Li, Wangliang1; Liu, Qingfen1; Liu, Huizhou1
2018-02-01
发表期刊CHINESE JOURNAL OF CHEMICAL ENGINEERING
ISSN1004-9541
卷号26期号:2页码:252-258
摘要Antibiotics mycelium, byproduct of pharmaceutical industry, contains high percentage of proteins, polysaccharides and lipids, while, the low solubility in traditional solvents limits its utilization. The dissolution process of penicillin mycelium was investigated using ionic liquids (ILs) as solvent. Quantitative correlation of solubility and ILs structure and dissolution mechanism were determined. About 91.45% of penicillin mycelium was dissolved in 1-butyl-3-methylimidazolium acetate ([Bmim]Ac) under the condition of 120.0 degrees C and [Bmim]Ac/mycelium (m/m) ratio of 3.90:1. Synergistic effect of ILs and DMSO was confirmed with the DMSO/Bmim]Ac (v/m) ratio in the range of 0.0-1.0. At 25.0 degrees C, the dissolution of penicillin mycelium increased from 69.74% to 94.50%, with the ratio of DMSO to [Bmim]Ac (v/m) as 1:1. The room temperature dissolution of mycelium provides a novel and energy-saving process for its high-valued utilization. The NMR and FT-IR spectra showed that hydrogen bonds are the dominant driving force for the dissolution in ILs. Quantitative study on the effects of anions and cations of ILs on dissolution using Kamlet-Taft model showed that there was a linearly positive correlation between solubility of penicillin mycelium and beta parameter of the ILs. The solubility of mycelium increased with increasing hydrogen bond accepting ability of anions and donating ability of cations. (C) 2017 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.
关键词Antibiotics Mycelium Ionic Liquids Dissolution Driving Force Kamlet-taft Parameters
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1016/j.cjche.2017.04.003
收录类别SCI
语种英语
关键词[WOS]CELLULOSE DISSOLUTION ; SOLVENT PROPERTIES ; NMR ; EXTRACTION ; SOLVATION ; ANIMALS ; SYSTEMS ; CHITIN ; WATER
WOS研究方向Engineering
WOS类目Engineering, Chemical
项目资助者National Natural Science Foundation of China(21676272) ; Major Science and Technology Program for Water Pollution Control and Treatment(2017ZX07402003) ; Key Research Program of the Chinese Academy of Sciences(ZDRW-ZS-2016-5-3)
WOS记录号WOS:000427859300005
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24069
专题湿法冶金清洁生产技术国家工程实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yang, Jierong,Li, Wangliang,Liu, Qingfen,et al. Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2018,26(2):252-258.
APA Yang, Jierong,Li, Wangliang,Liu, Qingfen,&Liu, Huizhou.(2018).Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism.CHINESE JOURNAL OF CHEMICAL ENGINEERING,26(2),252-258.
MLA Yang, Jierong,et al."Dissolution of antibiotics mycelium in ionic liquids: Performance and mechanism".CHINESE JOURNAL OF CHEMICAL ENGINEERING 26.2(2018):252-258.
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