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Macrophage responses to the physical burden of cell-sized particles
Yue, Hua1; Yuan, Lan2; Zhang, Weiwei3; Zhang, Shujia3; Wei, Wei1; Ma, Guanghui1,4,5
2018-01-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume6Issue:3Pages:393-400
AbstractThe role of a biophysical signal on cell response has excited tremendous interest recently. Herein, we exploited an "intake method'' together with uniform autofluorescent cell-sized particles to investigate macrophage responses against different particle burdens. Our work not only revealed an insatiable macrophage uptake of cell-sized microparticles (MPs) but also widened the theoretical size and volume range for particle entry. MPs outperform NPs in the utmost volume of intracellular particles, indicating a converse size-associated event than originally anticipated. Such a superior volume burden (2.64-fold of the cell volume) for MPs is highly correlated to less membrane loss (19-fold below that for NPs) and more evident deformation of the cell membrane/nucleus. In addition, the cells with a high burden of MPs exhibit moderate migration activity, which is in line with mild cytokine release. These results highlight the indispensable role of physical burden on the regulation of macrophage functions, providing important views for desired biological outcomes and minimal side effects.
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c7tb01673e
Indexed BySCI
Language英语
WOS KeywordVACCINE ADJUVANTS ; GRAPHENE OXIDE ; NANOPARTICLES ; DELIVERY ; MIGRATION ; DESIGN ; MICROPARTICLES ; IMMUNITY ; ARRAYS ; RGD
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China(51302265 ; Major Project of the Ministry of Science and Technology of China(2014ZX09102045) ; Beijing Talents Fund(2015000021223ZK20) ; Youth Innovation Promotion Association, CAS(2013033) ; 21622608)
WOS IDWOS:000422871100005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24084
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Peking Univ, Med & Hlth Anal Ctr, Beijing 100191, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Liaoning, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Yue, Hua,Yuan, Lan,Zhang, Weiwei,et al. Macrophage responses to the physical burden of cell-sized particles[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(3):393-400.
APA Yue, Hua,Yuan, Lan,Zhang, Weiwei,Zhang, Shujia,Wei, Wei,&Ma, Guanghui.(2018).Macrophage responses to the physical burden of cell-sized particles.JOURNAL OF MATERIALS CHEMISTRY B,6(3),393-400.
MLA Yue, Hua,et al."Macrophage responses to the physical burden of cell-sized particles".JOURNAL OF MATERIALS CHEMISTRY B 6.3(2018):393-400.
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