CAS OpenIR  > 生化工程国家重点实验室
Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination
Xia, Yufei1,2; Wu, Jie1,3; Wei, Wei1; Du, Yiqun1; Wan, Tao4,5; Ma, Xiaowei6; An, Wenqi6; Guo, Aiying6; Miao, Chunyu1; Yue, Hua1; Li, Shuoguo7; Cao, Xuetao4,5; Su, Zhiguo1,3,8; Ma, Guanghui1,3,8
2018-02-01
发表期刊NATURE MATERIALS
ISSN1476-1122
卷号17期号:2页码:187-+
摘要A major challenge in vaccine formulations is the stimulation of both the humoral and cellular immune response for well-defined antigens with high efficacy and safety. Adjuvant research has focused on developing particulate carriers to model the sizes, shapes and compositions of microbes or diseased cells, but not antigen fluidity and pliability. Here, we develop Pickering emulsions-that is, particle-stabilized emulsions that retain the force-dependent deformability and lateral mobility of presented antigens while displaying high biosafety and antigen-loading capabilities. Compared with solid particles and conventional surfactant-stabilized emulsions, the optimized Pickering emulsions enhance the recruitment, antigen uptake and activation of antigen-presenting cells, potently stimulating both humoral and cellular adaptive responses, and thus increasing the survival of mice upon lethal challenge. The pliability and lateral mobility of antigen-loaded Pickering emulsions may provide a facile, effective, safe and broadly applicable strategy to enhance adaptive immunity against infections and diseases.
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1038/NMAT5057
收录类别SCI
语种英语
关键词[WOS]T-CELL-ACTIVATION ; IMMUNE-RESPONSES ; CANCER ; VACCINES ; ANTIGEN ; ADJUVANTS ; DELIVERY ; NANOPARTICLES ; PHAGOCYTOSIS ; PERSISTENCE
WOS研究方向Chemistry ; Materials Science ; Physics
WOS类目Chemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National Science and Technology Major Project(2014ZX09102045) ; National Natural Science Foundation of China(21576268)
WOS记录号WOS:000423153800019
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24089
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
4.Second Mil Med Univ, State Key Lab Med Immunol, Shanghai 200433, Peoples R China
5.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
6.Hualan Biol Bacterin Co Ltd, Xinxiang 453003, Peoples R China
7.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China
8.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Xia, Yufei,Wu, Jie,Wei, Wei,et al. Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination[J]. NATURE MATERIALS,2018,17(2):187-+.
APA Xia, Yufei.,Wu, Jie.,Wei, Wei.,Du, Yiqun.,Wan, Tao.,...&Ma, Guanghui.(2018).Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination.NATURE MATERIALS,17(2),187-+.
MLA Xia, Yufei,et al."Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination".NATURE MATERIALS 17.2(2018):187-+.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia, Yufei]的文章
[Wu, Jie]的文章
[Wei, Wei]的文章
百度学术
百度学术中相似的文章
[Xia, Yufei]的文章
[Wu, Jie]的文章
[Wei, Wei]的文章
必应学术
必应学术中相似的文章
[Xia, Yufei]的文章
[Wu, Jie]的文章
[Wei, Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。