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Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination
Xia, Yufei1,2; Wu, Jie1,3; Wei, Wei1; Du, Yiqun1; Wan, Tao4,5; Ma, Xiaowei6; An, Wenqi6; Guo, Aiying6; Miao, Chunyu1; Yue, Hua1; Li, Shuoguo7; Cao, Xuetao4,5; Su, Zhiguo1,3,8; Ma, Guanghui1,3,8
2018-02-01
Source PublicationNATURE MATERIALS
ISSN1476-1122
Volume17Issue:2Pages:187-+
AbstractA major challenge in vaccine formulations is the stimulation of both the humoral and cellular immune response for well-defined antigens with high efficacy and safety. Adjuvant research has focused on developing particulate carriers to model the sizes, shapes and compositions of microbes or diseased cells, but not antigen fluidity and pliability. Here, we develop Pickering emulsions-that is, particle-stabilized emulsions that retain the force-dependent deformability and lateral mobility of presented antigens while displaying high biosafety and antigen-loading capabilities. Compared with solid particles and conventional surfactant-stabilized emulsions, the optimized Pickering emulsions enhance the recruitment, antigen uptake and activation of antigen-presenting cells, potently stimulating both humoral and cellular adaptive responses, and thus increasing the survival of mice upon lethal challenge. The pliability and lateral mobility of antigen-loaded Pickering emulsions may provide a facile, effective, safe and broadly applicable strategy to enhance adaptive immunity against infections and diseases.
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1038/NMAT5057
Indexed BySCI
Language英语
WOS KeywordT-CELL-ACTIVATION ; IMMUNE-RESPONSES ; CANCER ; VACCINES ; ANTIGEN ; ADJUVANTS ; DELIVERY ; NANOPARTICLES ; PHAGOCYTOSIS ; PERSISTENCE
WOS Research AreaChemistry ; Materials Science ; Physics
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Science and Technology Major Project(2014ZX09102045) ; National Natural Science Foundation of China(21576268)
WOS IDWOS:000423153800019
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24089
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
4.Second Mil Med Univ, State Key Lab Med Immunol, Shanghai 200433, Peoples R China
5.Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China
6.Hualan Biol Bacterin Co Ltd, Xinxiang 453003, Peoples R China
7.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China
8.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Xia, Yufei,Wu, Jie,Wei, Wei,et al. Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination[J]. NATURE MATERIALS,2018,17(2):187-+.
APA Xia, Yufei.,Wu, Jie.,Wei, Wei.,Du, Yiqun.,Wan, Tao.,...&Ma, Guanghui.(2018).Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination.NATURE MATERIALS,17(2),187-+.
MLA Xia, Yufei,et al."Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination".NATURE MATERIALS 17.2(2018):187-+.
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