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Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers
Zhang, Yue1,2; Yu, Xiao-lin1; Zhu, Jie1; Liu, Shu-ying1; Liu, Xiang-meng1; Dong, Quan-xiu1; Chai, Jia-qian2; Liu, Rui-tian1
2018
Source PublicationINTERNATIONAL IMMUNOPHARMACOLOGY
ISSN1567-5769
Volume54Pages:145-152
AbstractType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by beta-cell loss, insulin resistance, islet inflammation and amyloid deposits derived from islet amyloid polypeptide (IAPP). Reducing toxic IAPP oligomers and inhibiting islet inflammation may provide therapeutic benefit in treating T2DM. Intravenous immunoglobulin (IVIg) is an efficient anti-inflammatory and immunomodulatory agent for the treatment of several autoinunune or inflammatory neurological diseases. However, whether Wig has therapeutic potential on T2DM remains unclear. In present study, we showed that IVIg treatment significantly improved glucose control and insulin sensitivity, and prevented-cell apoptosis by lowering toxic IAPP oligomer levels, attenuating islet inflammation and activating autophagy in human IAPP transgenic mouse model. These results suggest that IVIg is a promising therapeutic potential for T2DM treatment.
KeywordType 2 Diabetes Mellitus Intravenous Immunoglobulin Islet Amyloid Polypeptide Islet Inflammation Toxic Oligomer
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.intimp.2017.11.012
Indexed BySCI
Language英语
WOS KeywordDIABETES-MELLITUS ; TARGETING INFLAMMATION ; INSULIN-RESISTANCE ; HUMAN-DISEASE ; KAPPA-B ; TOXICITY ; ACTIVATION ; MECHANISM ; ALZHEIMERS ; MANAGEMENT
WOS Research AreaImmunology ; Pharmacology & Pharmacy
WOS SubjectImmunology ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040215) ; 81402837) ; 2014ZX09102041-007)
WOS IDWOS:000423887900019
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24094
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shandong Agr Univ, Tai An 271018, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yue,Yu, Xiao-lin,Zhu, Jie,et al. Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2018,54:145-152.
APA Zhang, Yue.,Yu, Xiao-lin.,Zhu, Jie.,Liu, Shu-ying.,Liu, Xiang-meng.,...&Liu, Rui-tian.(2018).Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers.INTERNATIONAL IMMUNOPHARMACOLOGY,54,145-152.
MLA Zhang, Yue,et al."Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers".INTERNATIONAL IMMUNOPHARMACOLOGY 54(2018):145-152.
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