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Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice
Zheng, Junping1,2,3,4; Cheng, Gong3,4; Li, Qiongyu3,4; Jiao, Siming3,4; Feng, Cui3,4; Zhao, Xiaoming1; Yin, Heng1; Du, Yuguang3,4; Liu, Hongtao3,4,5
2018-02-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号16期号:2
摘要Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced metabolic syndrome by rebuilding the structure of the gut microbiota community. Male C57BL/6J mice fed with HFD were treated with NACOS (1 mg/mL) in drinking water for five months. The results indicate that NACOS improved glucose metabolic disorder in HFD-fed mice and suppressed mRNA expression of the protein regulators related to lipogenesis, gluconeogenesis, adipocyte differentiation, and inflammation in adipose tissues. Additionally, NACOS inhibited the destruction of the gut barrier in HFD-treated mice. Furthermore, 16S ribosome RNA sequencing of fecal samples demonstrates that NACOS promoted the growth of beneficial intestinal bacteria remarkably and decreased the abundance of inflammogenic taxa. In summary, NACOS partly rebuilt the microbial community and improved the metabolic syndrome of HFD-fed mice. These data confirm the preventive effects of NACOS on nutrient excess-related metabolic diseases.
关键词Chitin Oligosaccharide Gut Microbiota High-fat Diet Insulin Resistance Metabolic Syndrome
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3390/md16020066
收录类别SCI
语种英语
关键词[WOS]PANCREATIC-ISLET CELLS ; CHITOSAN OLIGOSACCHARIDE ; FECAL MICROBIOTA ; OBESE MICE ; DIABETES-MELLITUS ; RATS ; GLUCOSE ; SUPPLEMENTATION ; INFLAMMATION ; MODEL
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
项目资助者National Natural Science Foundation of China(31570801 ; National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; 31500747)
WOS记录号WOS:000427528800028
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24098
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, PLA, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, PLA, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China
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Zheng, Junping,Cheng, Gong,Li, Qiongyu,et al. Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice[J]. MARINE DRUGS,2018,16(2).
APA Zheng, Junping.,Cheng, Gong.,Li, Qiongyu.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2018).Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice.MARINE DRUGS,16(2).
MLA Zheng, Junping,et al."Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice".MARINE DRUGS 16.2(2018).
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