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Amino Acid Coordinated Self-Assembly
Zou, Qianli1; Yan, Xuehai1,2

Self-assembly of highly important biomolecules, such as proteins and peptides, has attracted tremendous interest in supramolecular construction of functional materials. However, as proteins and peptides are often immunogenic and their structures are complex, there is a strong demand to use amino acids as simpler building blocks. Still, mimicking the sophisticated structures and functions of natural materials by self-assembly of simpler and more basic units of biomolecules, such as amino acids, remains a formidable challenge. Inspired by metalion-associated crystallization of L-cystine in the urinary system, amino acid coordinated self-assembly is discussed as an original strategy for supramolecular construction of biomimetic materials. The resulting materials possess the features of uniform size, hierarchical architecture, and structural resemblance to biological structures. In addition, the self-assembly process can readily be adapted to simultaneous integration of various functional modules, providing materials with promising properties for biomimetic and biomedical applications.

KeywordAmino Acids Coordination Metal Ions Photosynthesis Self-assembly
WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
WOS KeywordMetal-biomolecule Frameworks ; Antitumor Therapy ; Urinary Stones ; Peptide ; Delivery ; Protein ; Chloroplast ; Nanoarchitectonics ; Nanostructures ; Organization
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 21773248 ; 91434103)
WOS IDWOS:000425822100002
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Yan, Xuehai. Amino Acid Coordinated Self-Assembly[J]. CHEMISTRY-A EUROPEAN JOURNAL,2018,24(4):755-761.
APA Zou, Qianli,&Yan, Xuehai.(2018).Amino Acid Coordinated Self-Assembly.CHEMISTRY-A EUROPEAN JOURNAL,24(4),755-761.
MLA Zou, Qianli,et al."Amino Acid Coordinated Self-Assembly".CHEMISTRY-A EUROPEAN JOURNAL 24.4(2018):755-761.
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