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Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging
Lv, Yanlin1,2; Liu, Ming3,4; Zhang, Yong3; Wang, Xuefei1; Zhang, Fan2; Li, Feng2; Bao, Wei-Er2; Wang, Jie1; Zhang, Yuanlin1; Wei, Wei2; Ma, Guanghui2; Zhao, Liancheng3; Tian, Zhiyuan1
2018-02-01
发表期刊ACS NANO
ISSN1936-0851
卷号12期号:2页码:1350-1358
摘要Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence (lambda(max) approximate to 720 nm) upon excitation of 800 nm light were developed. The key conjugated polymer enabled two-photon absorption and Forster resonance energy transfer (FRET) processes within the nanoprobes, which imparted the nanoprobes with ideal NIR-incoming-NIR-outgoing fluorescence features. The cancer cell membrane (CM) coating endowed these nanoprobes with perfect biocompatibility and highly specific targeting ability to homologous tumors. It was believed that CM encapsulation provided an additional protecting layer for the photoactive components residing in the core of nanoprobes for retaining their intrinsic fluorescing ability in the physiological milieu. The long-term structural integrity, excellent photostability (fluorescence decrease <10% upon 30 min illumination of 800 nm pulse laser), high NIR fluorescence quantum yield (similar to 20%), and long in vivo circulation time of the target nanoprobes were also confirmed. The ability of these feature-packed nanoprobes for circumventing the challenges of absorption and light scattering caused by cellular structures and tissues was definitely confirmed via in vivo and in vitro experiments. The superior performances of these nanoprobes in terms of fluorescence signaling as well as targeting specificity were verified in intravital fluorescence imaging on tumor-bearing model mice. Specifically, these nanoprobes unequivocally enabled high-resolution visualization of the fine heterogeneous architectures of intravital tumor tissue, which proclaims the great potential of this type of probe for high-contrast fluorescence detection of thick biological samples in practical applications.
关键词Two Photon Excitation Near-infrared Emission Cancer Cell Membrane Homologous Targeting Biological Imaging
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.7b07716
收录类别SCI
语种英语
关键词[WOS]REAL-TIME ; POLYMER NANOPARTICLES ; MICROSCOPY ; TISSUE ; PROBE ; LUMINESCENCE ; ZEBRAFISH ; CONTRAST ; THERAPY ; RANGE
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Key R&D Program of China(2017YFA0207900) ; State Key Laboratory of Luminescent Materials and Devices (South China University of Technology)(skllmd-2015-12) ; National Natural Science Foundation of China(91233107 ; Beijing Talents Fund(2015000021223ZK20) ; Fundamental Research Funds for the Central Universities (Harbin Institute of Technology) ; 21573234 ; 21373218 ; 21622608)
WOS记录号WOS:000426615600046
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24114
专题生化工程国家重点实验室
作者单位1.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Harbin Inst Technol, Sch Mat Sci & Engn, Harbin 150001, Heilongjiang, Peoples R China
4.Wuhan Inst Technol, Sch Mat Sci & Engn, Wuhan 403052, Hubei, Peoples R China
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GB/T 7714
Lv, Yanlin,Liu, Ming,Zhang, Yong,et al. Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging[J]. ACS NANO,2018,12(2):1350-1358.
APA Lv, Yanlin.,Liu, Ming.,Zhang, Yong.,Wang, Xuefei.,Zhang, Fan.,...&Tian, Zhiyuan.(2018).Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging.ACS NANO,12(2),1350-1358.
MLA Lv, Yanlin,et al."Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging".ACS NANO 12.2(2018):1350-1358.
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