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Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs
Wei, Jinhua1,2; Wang, Zhuo A.1,2; Wang, Bing1,3; Jahan, Marefa3; Wang, Zhongfu4; Wynn, Peter C.3; Du, Yuguang1,2
2018-03-16
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume8
AbstractMilk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from multiparous sows relative to gilts. We report 55 PMOs structures, of which 25 are new (17 sialylated and 8 neutral). Their incidence in gilt and sow colostrum was almost identical (53 vs. 54), but not in transitional milk (48 vs. 53) nor mature milk (41 vs. 47). These PMOs including neutral-, sialyl-and fucosyl-MOs in colostrum were more abundant in the gilt than the sow, but always decreased during lactation. Structural diversity decreased, although fucosylated MO were conserved. In conclusion, high diversity and levels of MO in porcine milk is parity dependent. Given the similarity between porcine and human MO profiles, our findings may help define key roles for MOs as potential dietary additives to improve growth of neonates from first pregnancies in both human and sows.
SubtypeArticle
WOS HeadingsScience & Technology
DOI10.1038/s41598-018-23025-x
Indexed BySCI
Language英语
WOS KeywordMASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; BOVINE-MILK ; COLOSTRUM INTAKE ; SIALIC ACIDS ; SOW MILK ; ANNOTATION ; QUANTIFICATION ; EVOLUTION ; ANIMALS
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationCharles Sturt University Postgraduate Research Scholarship ; Institute of Process Engineering, Chinese Academy of Sciences ; School of Animal and Veterinary Science, Charles Sturt University
WOS IDWOS:000427587600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24116
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.PLA, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
3.Charles Sturt Univ, Graham Ctr Agr Innovat, Wagga Wagga, NSW 2650, Australia
4.Northwest Univ, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Wei, Jinhua,Wang, Zhuo A.,Wang, Bing,et al. Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs[J]. SCIENTIFIC REPORTS,2018,8.
APA Wei, Jinhua.,Wang, Zhuo A..,Wang, Bing.,Jahan, Marefa.,Wang, Zhongfu.,...&Du, Yuguang.(2018).Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs.SCIENTIFIC REPORTS,8.
MLA Wei, Jinhua,et al."Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs".SCIENTIFIC REPORTS 8(2018).
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