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Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome
Xu, Qingsong1; Qu, Chen1; Wan, Jin2; Cheng, Gong3,4; Yang, Wen1; Gong, Changhao1; He, Jun2; Du, Yuguang3
Source PublicationRSC ADVANCES

Fecundity improvement is one of the most important economic traits for the swine industry as it significantly increases production efficiency. Intriguingly, chitosan oligosaccharide (COS), a biomaterial with an active amino group, could promote sow reproductive performance. Therefore, we investigated the effects of dietary COS supplementation on the gene expression differences in the ovaries of sows using the RNA-Seq method. This analysis obtained 13960051 and 14564863 clean reads in control ovary and COS ovary libraries, respectively. A total of 486 differentially expressed genes (DEGs) were thereby identified (FDR 0.001, |log(2)ratio| 1). There were 234 up-regulated and 252 down-regulated genes in the COS ovary samples compared with the control ovary samples. A large number of these DEGs were involved in the terms cellular process, cell & cell part and binding. Furthermore, pathway analysis indicated that these DEGs were significantly enriched in 34 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including cell cycle, progesterone-mediated oocyte maturation, metabolic pathways, oocyte meiosis, and hematopoietic cell lineage among others. These results provided the molecular mechanisms of using COS feed additive for improving sow litter size and prolificacy.

WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
WOS KeywordDifferentially Expressed Genes ; Rna-seq ; Biological-activities ; Pregnancy ; Reproduction ; Implantation ; Performance ; Nutrition ; Survival ; Insights
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationProgram for Innovative Talents in Higher Education of Liaoning Province ; Dalian high level talent innovation support program(2015R020) ; National Natural Science Foundation of China(31372347)
WOS IDWOS:000430018700028
Citation statistics
Document Type期刊论文
Affiliation1.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
4.Zhongke Runxin Suzhou Biol Technol Co Ltd, Suzhou 215000, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qingsong,Qu, Chen,Wan, Jin,et al. Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome[J]. RSC ADVANCES,2018,8(24):13266-13273.
APA Xu, Qingsong.,Qu, Chen.,Wan, Jin.,Cheng, Gong.,Yang, Wen.,...&Du, Yuguang.(2018).Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome.RSC ADVANCES,8(24),13266-13273.
MLA Xu, Qingsong,et al."Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome".RSC ADVANCES 8.24(2018):13266-13273.
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