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Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice
Zheng, Junping1,2,3,4; Yuan, Xubing2,3,4; Cheng, Gong3,4; Jiao, Siming3,4; Feng, Cui3,4; Zhao, Xiaoming1; Yin, Heng1; Du, Yuguang3,4; Liu, Hongtao3,4,5
2018-06-15
发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
卷号190页码:77-86
摘要The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.
关键词Chitosan Oligosaccharides Diabetes Gut Microbiota Intestinal Integrity Lipogenesis
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2018.02.058
收录类别SCI
语种英语
关键词[WOS]INTESTINAL MICROBIOTA ; INSULIN-RESISTANCE ; BARRIER FUNCTION ; CHITOOLIGOSACCHARIDES ; OLIGOFRUCTOSE ; INDIVIDUALS ; ENDOTOXEMIA ; EXPRESSION ; OBESITY ; INULIN
WOS研究方向Chemistry ; Polymer Science
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
项目资助者National Natural Science Foundation of China(31570801 ; National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; 31500747)
WOS记录号WOS:000429425500009
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24173
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, PLA, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, PLA, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China
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Zheng, Junping,Yuan, Xubing,Cheng, Gong,et al. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice[J]. CARBOHYDRATE POLYMERS,2018,190:77-86.
APA Zheng, Junping.,Yuan, Xubing.,Cheng, Gong.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2018).Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice.CARBOHYDRATE POLYMERS,190,77-86.
MLA Zheng, Junping,et al."Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice".CARBOHYDRATE POLYMERS 190(2018):77-86.
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