CAS OpenIR  > 生化工程国家重点实验室
Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice
Zheng, Junping1,2,3,4; Yuan, Xubing2,3,4; Cheng, Gong3,4; Jiao, Siming3,4; Feng, Cui3,4; Zhao, Xiaoming1; Yin, Heng1; Du, Yuguang3,4; Liu, Hongtao3,4,5
2018-06-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume190Pages:77-86
AbstractThe aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue. Additionally, COS treatment inhibited the reduction of occludin (P < 0.01) and relieved the gut dysbiosis in diabetic mice by promoting Akkermansia (P < 0.01) and suppressing Helicobacter (P < 0.05). Spearman's correlation analysis indicates that the COS-modulated bacteria are positively correlated with inflammation, hyperglycemia and dyslipidemia. The functional profiling based on the microbiota composition implicated that COS treatment may regulate the metabolic pathways of gut microbiota. In summary, COS treatment remarkably improved the glucose metabolism and reshaped the unbalanced gut microbiota of diabetic mice. Our study provided the evidence for application of COS to the treatment of diabetes mellitus.
KeywordChitosan Oligosaccharides Diabetes Gut Microbiota Intestinal Integrity Lipogenesis
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2018.02.058
Indexed BySCI
Language英语
WOS KeywordINTESTINAL MICROBIOTA ; INSULIN-RESISTANCE ; BARRIER FUNCTION ; CHITOOLIGOSACCHARIDES ; OLIGOFRUCTOSE ; INDIVIDUALS ; ENDOTOXEMIA ; EXPRESSION ; OBESITY ; INULIN
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China(31570801 ; National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; 31500747)
WOS IDWOS:000429425500009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24173
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, PLA, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, PLA, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Junping,Yuan, Xubing,Cheng, Gong,et al. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice[J]. CARBOHYDRATE POLYMERS,2018,190:77-86.
APA Zheng, Junping.,Yuan, Xubing.,Cheng, Gong.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2018).Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice.CARBOHYDRATE POLYMERS,190,77-86.
MLA Zheng, Junping,et al."Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice".CARBOHYDRATE POLYMERS 190(2018):77-86.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Junping]'s Articles
[Yuan, Xubing]'s Articles
[Cheng, Gong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Junping]'s Articles
[Yuan, Xubing]'s Articles
[Cheng, Gong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Junping]'s Articles
[Yuan, Xubing]'s Articles
[Cheng, Gong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.