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Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine
Wang, Shuang1,2; Ni, Dezhi1; Yue, Hua1; Luo, Nana1; Xi, Xiaobo1,2; Wang, Yugang3; Shi, Min3; Wei, Wei1; Ma, Guanghui1,2,4
2018-04-05
发表期刊SMALL
ISSN1613-6810
卷号14期号:14
摘要Therapeutic vaccines possess particular advantages and show promising potential to combat burdening diseases, such as acquired immunodeficiency syndrome, hepatitis, and even cancers. An efficient therapeutic vaccine would strengthen the immune system and eventually eliminate target cells through cytotoxic T lymphocytes (CTLs). Unfortunately, insufficient efficacy in triggering such an adaptive immune response is a problem that remains unsolved. To achieve efficient cellular immunity, antigen-presenting cells must capture and further cross-present disease-associated antigens to CD8 T cells via major histocompatibility complex I molecules. Here, a biomimetic strategy is developed to fabricate hierarchical ovalbumin@CaCO3 nanoparticles (OVA@NP, approximate to 500 nm) under the templating effect of antigen OVA. Taking advantage of the unique physicochemical properties of crystalline vaterite, cluster structure, and high loading, OVA@NP can efficiently ferry cargo antigen to dendritic cells and blast lysosomes for antigen escape to the cytoplasm. In addition, the first evidence that the physical stress from generated CO2 induces autophagy through the LC3/Beclin 1 pathways is presented. These outcomes cooperatively promote antigen cross-presentation, elicit CD8 T cell proliferation, ignite a potent and specific CTL response, and finally achieve prominent tumor therapy effects.
关键词Autophagy Calcium Carbonate Cross-presentation Lysosome Escape Nanoparticles
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/smll.201704272
收录类别SCI
语种英语
关键词[WOS]CROSS-PRESENTATION ; DENDRITIC CELLS ; CANCER-IMMUNOTHERAPY ; LIPOSOMAL SYSTEM ; DELIVERY ; RESPONSES ; IMMUNITY ; PEPTIDE ; BIOMINERALIZATION ; OVALBUMIN
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National Key R&D Program of China(2017YFA0207900) ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development"(2014ZX09102045-004) ; National Natural Science Foundation of China(21622608) ; Center for Mesoscience, Institute of Process Engineering, Chinese Academy of Science(COM2015A0006) ; Beijing Talents Fund(2015000021223ZK20)
WOS记录号WOS:000429579100024
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24180
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Dept Gastroenterol, Shanghai 200336, Peoples R China
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
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GB/T 7714
Wang, Shuang,Ni, Dezhi,Yue, Hua,et al. Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine[J]. SMALL,2018,14(14).
APA Wang, Shuang.,Ni, Dezhi.,Yue, Hua.,Luo, Nana.,Xi, Xiaobo.,...&Ma, Guanghui.(2018).Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine.SMALL,14(14).
MLA Wang, Shuang,et al."Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine".SMALL 14.14(2018).
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