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A reversible light-responsive assembly system based on host-guest interaction for controlled release
Yu, Jiemiao1; Qu, Hongnan1,2,3; Dong, Tingting1,3; Rong, Meng1,3; Yang, Liangrong1; Liu, Huizhou1,2
2018-04-21
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume42Issue:8Pages:6532-6537
Abstract

Here, we established a reversible light-responsive assembly system, which consisted of azobenzene grafted mesoporous silica nanoparticles (MSN-AZO) and cyclodextrin-functionalized Au nanoparticles (AuNP@CD). The assembly system was constructed by the host-guest interaction between azobenzene and beta-cyclodextrin. For controlled release, the cargo molecule fluorescein isothiocyanate (FITC) in the pores of the MSNs can be regulated or triggered by different wavelengths. Under visible light irradiation, the azobenzene on the MSN surface exhibits a trans-configuration, and can bind with b-cyclodextrin on the AuNPs by host-guest interaction. Thus the mesopores were closed by the AuNP@CD caps and cargo molecules were locked in the pores. While under UV irradiation, the azobenzene changed to cis-configuration, which cannot bind with b-cyclodextrin, leading to the disaggregation of the caps from the outer surface of the MSNs. Thus the cargo molecules were released from the pores. This light-responsive triggered system may have potential applications in drug-controlled release, light-responsive devices and novel catalytic processes.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c8nj00014j
Indexed BySCI
Language英语
WOS KeywordMesoporous Silica Nanoparticles ; Intracellular Controlled-release ; Drug-release ; Gold Nanoparticles ; Cancer-cells ; Delivery ; Nanocontainers ; Recognition ; Oxide ; Water
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21676273) ; National Key Natural Science Foundation of China(U1507203) ; National Technology Research and Development Program of China(2015CB251402) ; Youth Innovation Promotion Association, CAS(2016043)
WOS IDWOS:000430996700098
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24404
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yu, Jiemiao,Qu, Hongnan,Dong, Tingting,et al. A reversible light-responsive assembly system based on host-guest interaction for controlled release[J]. NEW JOURNAL OF CHEMISTRY,2018,42(8):6532-6537.
APA Yu, Jiemiao,Qu, Hongnan,Dong, Tingting,Rong, Meng,Yang, Liangrong,&Liu, Huizhou.(2018).A reversible light-responsive assembly system based on host-guest interaction for controlled release.NEW JOURNAL OF CHEMISTRY,42(8),6532-6537.
MLA Yu, Jiemiao,et al."A reversible light-responsive assembly system based on host-guest interaction for controlled release".NEW JOURNAL OF CHEMISTRY 42.8(2018):6532-6537.
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