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Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation
Cao, Weifeng1; Wang, Yujue1,2; Luo, Jianquan1,2; Yin, Junxiang3; Wan, Yinhua1,2
2018-07-01
发表期刊BIORESOURCE TECHNOLOGY
ISSN0960-8524
卷号260页码:9-15
摘要The aim of the present study is to develop an effective production process for a, omega-dodecanedioic acid (DC12) biosynthesis using n-dodecane and hydrolysate of Candida cells as substrates by membrane integrated repeated batch fermentation. Cells and n-dodecane were simultaneously recycled during the filtration of fermentation broth (FB) with a 150 kDa ceramic membrane under a cross-flow velocity of 4 m/s and a trans-membrane pressure of 0.2 MPa, and it was also revealed that the cells in the broth could alleviate the membrane fouling during the FB filtration. Moreover, the hydrolysate of the collected cells could be successfully used as a nitrogen source to replace 50% yeast extract for decreasing the DC12 production cost. With repeated-batch culture in a membrane bioreactor, the maximal DC12 productivity could be enhanced by 57.8% compared with the batch culture, meanwhile n-dodecane and cells could be recovered and used for the next fermentation cycle.
关键词Hydrolysate Of Candida Cells Alpha Candida Viswanathii Omega-dodecanedioic Acid Membrane Bioreactor Alpha Omega-dicarboxylic Acids
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1016/j.biortech.2018.03.070
收录类别SCI ; ISTP
语种英语
关键词[WOS]CHAIN DICARBOXYLIC-ACIDS ; YARROWIA-LIPOLYTICA ; MATHEMATICAL-MODEL ; WATER TREATMENT ; WASTE-WATER ; TROPICALIS ; SYSTEM ; ULTRAFILTRATION ; VISWANATHII ; MECHANISMS
WOS研究方向Agriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS类目Agricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
项目资助者National High Technology Research and Development Program of China(2015AA0210022015AA021002) ; National Science Foundation of China(21406240)
WOS记录号WOS:000430969800002
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24408
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.China Natl Ctr Biotechnol Dev, Beijing 100036, Peoples R China
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GB/T 7714
Cao, Weifeng,Wang, Yujue,Luo, Jianquan,et al. Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation[J]. BIORESOURCE TECHNOLOGY,2018,260:9-15.
APA Cao, Weifeng,Wang, Yujue,Luo, Jianquan,Yin, Junxiang,&Wan, Yinhua.(2018).Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation.BIORESOURCE TECHNOLOGY,260,9-15.
MLA Cao, Weifeng,et al."Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation".BIORESOURCE TECHNOLOGY 260(2018):9-15.
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