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Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation
Cao, Weifeng1; Wang, Yujue1,2; Luo, Jianquan1,2; Yin, Junxiang3; Wan, Yinhua1,2
2018-07-01
Source PublicationBIORESOURCE TECHNOLOGY
ISSN0960-8524
Volume260Pages:9-15
Abstract

The aim of the present study is to develop an effective production process for a, omega-dodecanedioic acid (DC12) biosynthesis using n-dodecane and hydrolysate of Candida cells as substrates by membrane integrated repeated batch fermentation. Cells and n-dodecane were simultaneously recycled during the filtration of fermentation broth (FB) with a 150 kDa ceramic membrane under a cross-flow velocity of 4 m/s and a trans-membrane pressure of 0.2 MPa, and it was also revealed that the cells in the broth could alleviate the membrane fouling during the FB filtration. Moreover, the hydrolysate of the collected cells could be successfully used as a nitrogen source to replace 50% yeast extract for decreasing the DC12 production cost. With repeated-batch culture in a membrane bioreactor, the maximal DC12 productivity could be enhanced by 57.8% compared with the batch culture, meanwhile n-dodecane and cells could be recovered and used for the next fermentation cycle.

KeywordHydrolysate Of Candida Cells Alpha Candida Viswanathii Omega-dodecanedioic Acid Membrane Bioreactor Alpha Omega-dicarboxylic Acids
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1016/j.biortech.2018.03.070
Indexed BySCI
Language英语
WOS KeywordChain Dicarboxylic-acids ; Yarrowia-lipolytica ; Mathematical-model ; Water Treatment ; Waste-water ; Tropicalis ; System ; Ultrafiltration ; Viswanathii ; Mechanisms
WOS Research AreaAgriculture ; Biotechnology & Applied Microbiology ; Energy & Fuels
WOS SubjectAgricultural Engineering ; Biotechnology & Applied Microbiology ; Energy & Fuels
Funding OrganizationNational High Technology Research and Development Program of China(2015AA0210022015AA021002) ; National Science Foundation of China(21406240)
WOS IDWOS:000430969800002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24408
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.China Natl Ctr Biotechnol Dev, Beijing 100036, Peoples R China
Recommended Citation
GB/T 7714
Cao, Weifeng,Wang, Yujue,Luo, Jianquan,et al. Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation[J]. BIORESOURCE TECHNOLOGY,2018,260:9-15.
APA Cao, Weifeng,Wang, Yujue,Luo, Jianquan,Yin, Junxiang,&Wan, Yinhua.(2018).Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation.BIORESOURCE TECHNOLOGY,260,9-15.
MLA Cao, Weifeng,et al."Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation".BIORESOURCE TECHNOLOGY 260(2018):9-15.
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