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Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin
Tang, Jinglong1,2,3; Zhang, Ruirui1,2,4; Guo, Mengyu1,2; Shao, Leihou1,2; Liu, Ying1,2; Zhao, Yuliang1,2; Zhang, Suojiang4; Wu, Yan1,2; Chen, Chunying1,2
2018-06-01
发表期刊BIOMATERIALS
ISSN0142-9612
卷号167页码:205-215
摘要Chemodrugs have been widely used to treat cancer; however, the chemotherapy usually leads to serious side effects and failure. Various nanomaterials and strategies have been explored for drug delivery to improve the efficacy of chemodrugs. One key to loading chemodrugs onto a nano-delivery system is enhancement of the encapsulation efficiency, especially for polymeric nanoparticles being loaded with hydrophilic drugs. Inspired by the ability of eukaryote to package millions of genes in the nucleus wrapping and condensing DNA around histones to form chromosomes, here we developed a karyon-like hybrid nanoparticle to achieve ultra-high encapsulation of doxorubicin (Dox) with reduced side effects. We utilized fullerenol as a "histone", packaged a great number of Dox, and used PEG-PLGA as the "karyotheca" coating the "nucleosome" (fullerenol and Dox complex) to stabilize the complex. It is noteworthy that the encapsulation efficiency of Dox in the polymeric micelles was increased from similar to 5% to similar to 79%. What's more, the biomimetic-inspired delivery system significantly reduced the chemodrug side effects by utilizing the radical scavenging ability of fullerenol. This novel drug-delivery design approach provides useful insights for improving the applicability of fullerenol in drug delivery systems for cancer therapy. (C) 2018 Elsevier Ltd. All rights reserved.
关键词Fullerenol Doxorubicin Peg-plga Encapsulation Efficiency Reduced Side Effects
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1016/j.biomaterials.2018.03.015
收录类别SCI
语种英语
关键词[WOS]PLGA-PEG NANOPARTICLES ; INDUCED CARDIOTOXICITY ; INDUCED TOXICITY ; CELLULAR UPTAKE ; GRAPHENE OXIDE ; CANCER-THERAPY ; DELIVERY ; C-60(OH)(24) ; CYTOTOXICITY ; ATORVASTATIN
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
项目资助者Ministry of Science and Technology of China (National Basic Research Program)(2016YFA0201600) ; National Science Foundation of China(21320102003 ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China(11621505) ; CAS Key Research Program for Frontier Sciences(QYZDJ-SS-SLH022) ; CAS Interdisciplinary Innovation Team ; Project of Beijing National Science Foundation(2174085) ; National Science Fund for Distinguished Young Scholars(11425520) ; U1532122 ; 31571027 ; 21705151)
WOS记录号WOS:000430899200017
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24414
专题多相复杂系统国家重点实验室
作者单位1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
3.Qingdao Univ, Sch Publ Hlth, Qingdao 226021, Peoples R China
4.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
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Tang, Jinglong,Zhang, Ruirui,Guo, Mengyu,et al. Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin[J]. BIOMATERIALS,2018,167:205-215.
APA Tang, Jinglong.,Zhang, Ruirui.,Guo, Mengyu.,Shao, Leihou.,Liu, Ying.,...&Chen, Chunying.(2018).Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin.BIOMATERIALS,167,205-215.
MLA Tang, Jinglong,et al."Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin".BIOMATERIALS 167(2018):205-215.
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