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Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand foot-and-mouth disease
Wang, Chunhua1,2,3; Zhou, Shuaifeng4; Xue, Wanhua5; Shen, Liang2; Huang, Wei4; Zhang, Yi2; Li, Xuguang6; Wang, Junzhi1; Zhang, Hong4; Ma, Xuejun2
2018-05-01
发表期刊VIROLOGY
ISSN0042-6822
卷号518页码:116-125
摘要The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was performed using next-generation sequencing (NGS). The data revealed total thirteen mammalian- and plant virus families and diverse viral populations including enteroviruses, common respiratory viruses, diarrhea-related viruses, plant viruses and anelloviruses. A total of 18 viruses from 7 virus families were identified in severe cases, versus 37 viruses from 12 virus families in mild cases. Moreover, complicated mixed-infections of enteroviruses with common respiratory viruses were mainly found in severe cases(P = 0.013), while diarrhea related viruses were mainly found in mild cases(P < 0.001). This study provides the preliminary understanding of viromes both in mild and severe cases, which may benefit the detection of etiologic agents and prevention of HFMD.
关键词Next-generation Sequencing Virome Complexity Diversity Severe Hfmd Mild Hfmd
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.virol.2018.02.004
收录类别SCI
语种英语
WOS研究方向Virology
WOS类目Virology
项目资助者National Key Research and Development Plan of China(2016TFC1202700 ; China Mega-Project for Infectious Disease(2013ZX10004202-001-003 ; Chinese Preventive Medicine Association(20101801) ; 2016YFC1200900 ; 2017ZX10302301-004 ; 2017YFC1200503) ; 2017ZX10104001)
WOS记录号WOS:000431388000013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24424
专题研究所(批量导入)
作者单位1.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China
2.Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol, Beijing 102206, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
4.Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Hunan, Peoples R China
5.Dezhou Peoples Hosp, Dezhou 253056, Shandong, Peoples R China
6.Hlth Canada, Biol & Genet Therapies Directorate, Ottawa, ON 2201C, Canada
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Wang, Chunhua,Zhou, Shuaifeng,Xue, Wanhua,et al. Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand foot-and-mouth disease[J]. VIROLOGY,2018,518:116-125.
APA Wang, Chunhua.,Zhou, Shuaifeng.,Xue, Wanhua.,Shen, Liang.,Huang, Wei.,...&Ma, Xuejun.(2018).Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand foot-and-mouth disease.VIROLOGY,518,116-125.
MLA Wang, Chunhua,et al."Comprehensive virome analysis reveals the complexity and diversity of the viral spectrum in pediatric patients diagnosed with severe and mild hand foot-and-mouth disease".VIROLOGY 518(2018):116-125.
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