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Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment
Qiao, Chenmeng1,2,3; Yang, Jun1; Shen, Qi1; Liu, Ruiyuan1; Li, Yanhui1; Shi, Yuanjie1; Chen, Jingli1; Shen, Yanqin3; Xiao, Zuobing4,5; Weng, Jie2; Zhang, Xin1
2018-05-03
发表期刊ADVANCED MATERIALS
ISSN0935-9648
卷号30期号:18
摘要The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor microenvironment, especially the tumor growth factor beta (TGF-beta), an immunosuppressive cytokine. In this study, it is proposed to employ RNAi-based immunomodulation to modify the tumor immune microenvironment and improve the effect of chemotherapy. Herein, a nanotheranostic system (Angiopep LipoPCB(Temozolomide+BAP/siTGF-beta), ALBTA) with dual targeting and ROS response is established for intracranial glioblastoma treatment. The traceable nanoparticles exhibit strong siRNA condensation, high drug loading efficiency, good serum stability, and magnetic property. They can efficiently cross the blood-brain barrier and target to glioblastoma cells via receptor-mediated transcytosis. The zwitterionic lipid (distearoyl phosphoethanol-amine-polycarboxybetaine lipid) in ALBTA promotes endosomal/lysosomal escape, and thus enhances the cytotoxicity of temozolomide and improves gene silencing efficiency of siTGF-beta ALBTA significantly improves the immunosuppressive microenvironment and prolongs the survival time of glioma-bearing mice. Moreover, ALBTA can be accurately traced by MRI in brain tumors. The study indicates that this immunochemotherapeutic platform can serve as a flexible and powerful synergistic system for treatment with brain tumors as well as other brain diseases in central nervous system.
关键词Immunochemotherapy Intracranial Brain Tumors Magnetic Resonance Imaging (Mri) Temozolomide (Tmz) Tumor Growth Factor-beta (Tgf-beta)
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201705054
收录类别SCI
语种英语
关键词[WOS]SMALL INTERFERING RNA ; TUMOR MICROENVIRONMENT ; CATIONIC LIPOSOMES ; MALIGNANT GLIOMA ; CANCER-THERAPY ; DRUG-DELIVERY ; IN-VITRO ; MECHANISMS ; TEMOZOLOMIDE ; STRATEGY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51573188 ; "Strategic Priority Research Program" of the Chinese Academy of Sciences(XDA09030301-3) ; Beijing Municipal Science & Technology Commission(Z161100002616015) ; 31522023 ; 51373177)
WOS记录号WOS:000431615100003
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24434
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Southwest Jiaotong Univ, Key Lab Adv Technol Mat MOE, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
3.Jiangnan Univ, Wuxi Med Coll, Wuxi 214122, Peoples R China
4.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
5.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
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GB/T 7714
Qiao, Chenmeng,Yang, Jun,Shen, Qi,et al. Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment[J]. ADVANCED MATERIALS,2018,30(18).
APA Qiao, Chenmeng.,Yang, Jun.,Shen, Qi.,Liu, Ruiyuan.,Li, Yanhui.,...&Zhang, Xin.(2018).Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment.ADVANCED MATERIALS,30(18).
MLA Qiao, Chenmeng,et al."Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment".ADVANCED MATERIALS 30.18(2018).
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