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Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment
Qiao, Chenmeng1,2,3; Yang, Jun1; Shen, Qi1; Liu, Ruiyuan1; Li, Yanhui1; Shi, Yuanjie1; Chen, Jingli1; Shen, Yanqin3; Xiao, Zuobing4,5; Weng, Jie2; Zhang, Xin1
2018-05-03
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume30Issue:18
Abstract

The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor microenvironment, especially the tumor growth factor beta (TGF-beta), an immunosuppressive cytokine. In this study, it is proposed to employ RNAi-based immunomodulation to modify the tumor immune microenvironment and improve the effect of chemotherapy. Herein, a nanotheranostic system (Angiopep LipoPCB(Temozolomide+BAP/siTGF-beta), ALBTA) with dual targeting and ROS response is established for intracranial glioblastoma treatment. The traceable nanoparticles exhibit strong siRNA condensation, high drug loading efficiency, good serum stability, and magnetic property. They can efficiently cross the blood-brain barrier and target to glioblastoma cells via receptor-mediated transcytosis. The zwitterionic lipid (distearoyl phosphoethanol-amine-polycarboxybetaine lipid) in ALBTA promotes endosomal/lysosomal escape, and thus enhances the cytotoxicity of temozolomide and improves gene silencing efficiency of siTGF-beta ALBTA significantly improves the immunosuppressive microenvironment and prolongs the survival time of glioma-bearing mice. Moreover, ALBTA can be accurately traced by MRI in brain tumors. The study indicates that this immunochemotherapeutic platform can serve as a flexible and powerful synergistic system for treatment with brain tumors as well as other brain diseases in central nervous system.

KeywordImmunochemotherapy Intracranial Brain Tumors Magnetic Resonance Imaging (Mri) Temozolomide (Tmz) Tumor Growth Factor-beta (Tgf-beta)
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201705054
Indexed BySCI
Language英语
WOS KeywordSmall Interfering Rna ; Tumor Microenvironment ; Cationic Liposomes ; Malignant Glioma ; Cancer-therapy ; Drug-delivery ; In-vitro ; Mechanisms ; Temozolomide ; Strategy
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51573188
WOS IDWOS:000431615100003
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24434
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Southwest Jiaotong Univ, Key Lab Adv Technol Mat MOE, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
3.Jiangnan Univ, Wuxi Med Coll, Wuxi 214122, Peoples R China
4.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
5.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Chenmeng,Yang, Jun,Shen, Qi,et al. Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment[J]. ADVANCED MATERIALS,2018,30(18).
APA Qiao, Chenmeng.,Yang, Jun.,Shen, Qi.,Liu, Ruiyuan.,Li, Yanhui.,...&Zhang, Xin.(2018).Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment.ADVANCED MATERIALS,30(18).
MLA Qiao, Chenmeng,et al."Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment".ADVANCED MATERIALS 30.18(2018).
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