Engineered biomaterials for development of nucleic acid vaccines
Yang,Jun1; Li,Yan1,4; Jin,Shubin2; Xu,Jing2; Wang,Paul C3; Liang,Xing-Jie2; Zhang,Xin1
Source PublicationBiomaterials Research
AbstractAbstractNucleic acid vaccines have attracted many attentions since they have presented some superiority over traditional vaccines. However, they could only induce moderate immunogenicity. The route and formulation of nucleic acid vaccines have strong effects on the immune response and efficiency. Numerous biomaterials are used as a tool to enhance the immunogenicity of antigens. They deliver the antigens into the cells through particle- and non-particle-mediated pathway. However, challenges remain due to lack of comprehensive understanding of the actions of these biomaterials as a carrier/adjuvant. Herein, this review focuses on the evolution of biomaterials used for nucleic acid vaccines, discusses the advantages and disadvantages for gene delivery and immunostimulation of variety of structures of the biomaterials, in order to provide new thought on rational design of carrier/adjuvant and better understanding of mechanism of action in both immunostimulatory and delivery methods.
KeywordNucleic acid vaccine Biomaterials Gene delivery Adjuvant Immunogenicity
WOS IDBMC:10.1186/s40824-014-0025-8
PublisherBioMed Central
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Document Type期刊论文
Corresponding AuthorLiang,Xing-Jie; Zhang,Xin
Affiliation1.Institute of Process Engineering, Chinese Academy of Sciences; National Key Laboratory of Biochemical Engineering
2.National Center for Nanoscience and Technology; CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety
3.Howard University; Laboratory of Molecular Imaging, Department of Radiology
4.University of Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang,Jun,Li,Yan,Jin,Shubin,et al. Engineered biomaterials for development of nucleic acid vaccines[J]. Biomaterials Research,2015,19(1).
APA Yang,Jun.,Li,Yan.,Jin,Shubin.,Xu,Jing.,Wang,Paul C.,...&Zhang,Xin.(2015).Engineered biomaterials for development of nucleic acid vaccines.Biomaterials Research,19(1).
MLA Yang,Jun,et al."Engineered biomaterials for development of nucleic acid vaccines".Biomaterials Research 19.1(2015).
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