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Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy
Zhang, Ling-xiao1,3; Xie, Xi-xiu1; Liu, Dong-qun1,3; Xu, Zhi Ping2; Liu, Rui-tian1
2018-08-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume174Pages:54-66
Abstract

Cancer immunotherapy has shown tremendous progresses in recent years for various cancers and layered double hydroxide (LDH) nanoparticles are demonstrated as effective adjuvants for protein-based vaccines. This research further shows that the colloidal stability of LDH-based vaccines significantly influences the therapeutic efficacy and LDH nanoparticles are able to adjuvant multiple tumor-associated antigen peptides to provoke strong cell-mediated immune responses for effective inhibition of cancer growth. The LDH-based multi-target therapeutic vaccines were constructed by assembling epitope peptides and CpG onto LDH nanoparticles. Using melanoma as the model cancer and Tyrosinase-related protein 2 (Trp2) peptide as the model antigen, we demonstrated that dispersion-stable LDH-based vaccine induced stronger cytotoxic T-lymphocyte (CTL) responses and significantly inhibited tumor growth in comparison with aggregated LDH-based vaccine. We further constructed multi-target dispersion-stable LDH-based vaccine by co-loading Trp2, two mutated epitopes (M27 and M30) and CpG, which showed remarkable inhibition of melanoma growth. These results suggest that dispersion stable LDH nanoparticles are an ideal platform to load multi-antigens and immune stimulants as effective personalized therapeutic cancer vaccines. (C) 2018 Elsevier Ltd. All rights reserved.

KeywordTherapeutic Cancer Vaccine Layered Double Hydroxides Colloidal Stability Personalized Immunotherapy Melanoma
DOI10.1016/j.biomaterials.2018.05.015
Language英语
WOS KeywordT-lymphocyte Responses ; Cancer-immunotherapy ; Trp2 Peptide ; Colloidal Stability ; Immune-responses ; Cellular Uptake ; Tumor-growth ; Dna Vaccine ; Albumin ; Cells
Funding ProjectNational Natural Science Foundation of China[81371208] ; Chinese Academy of Sciences Strategic Pilot Project[XDA12040215] ; Australian Research Council (ARC)[DP170104643]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China ; Chinese Academy of Sciences Strategic Pilot Project ; Australian Research Council (ARC)
WOS IDWOS:000436223500005
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25028
Collection生化工程国家重点实验室
Corresponding AuthorXu, Zhi Ping; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling-xiao,Xie, Xi-xiu,Liu, Dong-qun,et al. Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy[J]. BIOMATERIALS,2018,174:54-66.
APA Zhang, Ling-xiao,Xie, Xi-xiu,Liu, Dong-qun,Xu, Zhi Ping,&Liu, Rui-tian.(2018).Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy.BIOMATERIALS,174,54-66.
MLA Zhang, Ling-xiao,et al."Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy".BIOMATERIALS 174(2018):54-66.
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