CAS OpenIR  > 生化工程国家重点实验室
Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan
Zhang, Guiqiang1,2,3; Liu, Jing2,3,4; Li, Ruilian1,2,3; Jiao, Siming2,3; Feng, Cui2,3; Wang, Zhuo A.2,3; Du, Yuguang1,2,3
2018-05-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:5Pages:13
AbstractBacteria biofilm helps bacteria prevent phagocytosis during infection and increase resistance to antibiotics. Staphylococcus aureus is a Gram-positive pathogenic bacterium and is tightly associated with biofilm-related infections, which have led to great threat to human health. Chitosan, the only cationic polysaccharide in nature, has been demonstrated to have antimicrobial and anti-biofilm activities, which, however, require a relative high dosage of chitosan. Moreover, poor water solubility further restricts its applications on anti-infection therapy. Inulins are a group of polysaccharides produced by many types of plants, and are widely used in processed foods. Compared to chitosan, inulin is very soluble in water and possesses a mild antibacterial activity against certain pathogenic bacteria. In order to develop an effective strategy to treat biofilm-related infections, we introduce a method by covalent conjugation of inulin to chitosan. The physicochemical characterization of the inulin-chitosan conjugate was assayed, and the anti-biofilm activity was evaluated against S. aureus biofilm. The results indicated that, as compared to chitosan, this novel polysaccharide-polysaccharide conjugate significantly enhanced activities against S. aureus either in a biofilm or planktonic state. Of note, the conjugate also showed a broad spectrum anti-biofilm activity on different bacteria strains and low cellular toxicity to mammalian cells. These results suggested that chitosan conjugation of inulin was a viable strategy for treatment against biofilm-related infections. This finding may further spread the application of natural polysaccharides on treatments of infectious disease.
KeywordStaphylococcus aureus biofilm chitosan conjugation inulin
DOI10.3390/md16050151
Language英语
WOS KeywordINFECTIONS ; DERIVATIVES ; CHITIN ; AGENT ; MODE ; MICE
Funding ProjectNational Natural Science Fund, China[31670809]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
Funding OrganizationNational Natural Science Fund, China
WOS IDWOS:000435195100014
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25030
Collection生化工程国家重点实验室
Corresponding AuthorWang, Zhuo A.; Du, Yuguang
Affiliation1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Guiqiang,Liu, Jing,Li, Ruilian,et al. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan[J]. MARINE DRUGS,2018,16(5):13.
APA Zhang, Guiqiang.,Liu, Jing.,Li, Ruilian.,Jiao, Siming.,Feng, Cui.,...&Du, Yuguang.(2018).Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan.MARINE DRUGS,16(5),13.
MLA Zhang, Guiqiang,et al."Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan".MARINE DRUGS 16.5(2018):13.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Guiqiang]'s Articles
[Liu, Jing]'s Articles
[Li, Ruilian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Guiqiang]'s Articles
[Liu, Jing]'s Articles
[Li, Ruilian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Guiqiang]'s Articles
[Liu, Jing]'s Articles
[Li, Ruilian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.