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Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy
Li, Shukun1,3; Xing, Ruirui1; Chang, Rui1,3; Zou, Qianli1,2; Yan, Xuehai1,2,3
2018-05-01
Source PublicationCURRENT OPINION IN COLLOID & INTERFACE SCIENCE
ISSN1359-0294
Volume35Pages:17-25
Abstract

In this review we consider assembled nanodrugs as a type of nanoscale drugs formed by molecular self-assembly and associated with precise organization of multiple non-covalent interactions. Their typical feature is that the drug itself is considered as one of the building blocks with flexibly interplaying interaction for supramolecular assembly and nanostructure formation with robust stability and high loading efficiency in a controlled and tunable way. The super stability with retained function results from the "hydrophobic effect" of supramolecular self assembly of peptides and drugs. It is the hydrophobic effect responsible for both colloidal stability and circulation stability in body against dilution and blood-flow shearing. The assembled nanodrugs are distinguished from conventional ones with encapsulation of the drugs in delivery nanocarriers. We will focus on how peptides and peptide-conjugates can be designed for controlling and mediating the formation of the assembled nanodrugs. Emphasis will be put on the rational design of intermolecular interactions between drugs and peptides, in vitro and in vivo drug delivery and antitumor therapeutic effects. Finally, we will discuss the key challenges and promising perspectives of such kind of peptide-mediated assembled nanodrugs for both technical advances and potential clinical translation. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordPeptides Intermolecular Interactions Self-assembly Nanodrugs Tumor Therapy
DOI10.1016/j.cocis.2017.12.004
Language英语
WOS KeywordAnticancer Drug-delivery ; Cancer-therapy ; Supramolecular Nanostructures ; Photodynamic Therapy ; Clinical-applications ; Functional Materials ; Amphiphilic Peptide ; Hydrophobic Drugs ; Antitumor Therapy ; Serum-albumin
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[91434103] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2017DE0004] ; CAS President's International Fellowship Initiative[2017VEA0023]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative
WOS IDWOS:000440959900005
PublisherELSEVIER SCIENCE LONDON
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25454
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, 1 North Second St, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Shukun,Xing, Ruirui,Chang, Rui,et al. Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy[J]. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE,2018,35:17-25.
APA Li, Shukun,Xing, Ruirui,Chang, Rui,Zou, Qianli,&Yan, Xuehai.(2018).Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy.CURRENT OPINION IN COLLOID & INTERFACE SCIENCE,35,17-25.
MLA Li, Shukun,et al."Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy".CURRENT OPINION IN COLLOID & INTERFACE SCIENCE 35(2018):17-25.
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