CAS OpenIR
Stability of penicillin G in ionic liquid [Bmim]PF6
Qi, Jingxian; Liu, Qingfen; Liu, Huizhou
2018-06-01
Source PublicationCHINESE JOURNAL OF CHEMICAL ENGINEERING
ISSN1004-9541
Volume26Issue:6Pages:1430-1434
AbstractThe extraction of penicillin G by ionic liquid [Bmim] PF6 has exhibited promising prospect. The stability of penicillin G is crucial for developing a green ionic liquid-based extraction technology. In this work, the stability of penicillin G in [Bmim] PF6 was systematically investigated. The results showed the stability of penicillin G was significantly influenced by pH and temperature. It tended to be more stable when pH value increased from 1.5 to 4.0 and the temperature gradually decreased. The half-life (t(1/2)) of penicillin G in [Bmim] PF6 was 17.7 h in the optimal technological condition (pH 2.0 and 10 degrees C), which is enough for the requirement of extraction technology. The reaction of penicillinG in [Bmim] PF6 followed the first order kinetics in the pHrange 2.0-4.0. Three isomers of penicillin G were found through rearrangement at pH 2.0, and their structures were not affected by temperature. (C) 2018 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.
KeywordPenicillin G Ionic liquids Stability Rearrangement Kinetics
DOI10.1016/j.cjche.2018.02.030
Language英语
WOS KeywordAQUEOUS 2-PHASE SYSTEM ; WASTE-WATER ; DEGRADATION-PRODUCTS ; RESISTANCE GENES ; RECEIVING RIVER ; EXTRACTION ; TEMPERATURE ; SEPARATION ; SOLVENT ; FATE
Funding ProjectNational Natural Science Foundation of China[21676272] ; Major Science and Technology Project of Water Pollution Control and Management in China[2017ZX07402003] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-ZS-2016-5-3]
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
Funding OrganizationNational Natural Science Foundation of China ; Major Science and Technology Project of Water Pollution Control and Management in China ; Key Research Program of the Chinese Academy of Sciences
WOS IDWOS:000440837100022
PublisherCHEMICAL INDUSTRY PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25493
Collection中国科学院过程工程研究所
Corresponding AuthorLiu, Qingfen; Liu, Huizhou
AffiliationChinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Qi, Jingxian,Liu, Qingfen,Liu, Huizhou. Stability of penicillin G in ionic liquid [Bmim]PF6[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2018,26(6):1430-1434.
APA Qi, Jingxian,Liu, Qingfen,&Liu, Huizhou.(2018).Stability of penicillin G in ionic liquid [Bmim]PF6.CHINESE JOURNAL OF CHEMICAL ENGINEERING,26(6),1430-1434.
MLA Qi, Jingxian,et al."Stability of penicillin G in ionic liquid [Bmim]PF6".CHINESE JOURNAL OF CHEMICAL ENGINEERING 26.6(2018):1430-1434.
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