CAS OpenIR
Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System
Lu, Zhiguo1,4; Zheng, Yongchang2,3; Zhang, Tianlu1; Shen, Jie1,4; Xiao, Zuobing5,6; Hu, Jing5,6; Niu, Yunwei5,6; Yu, Dan5,6; Zhang, Xin1
2018-10-01
Source PublicationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN1550-7033
Volume14Issue:10Pages:1675-1687
Abstract

Many kinds of fragrances have the effects on life cultivation and health preservation. These fragrances can be used for emotional regulation, partly because of the way it can modulate our central nervous system (CNS), further affect our moods and even improve our behaviour. But the effects are very dependent on their concentrations in the air. In this study, photo-responsive micelles named as PPMM-PEG@S803 were designed and prepared to encapsulate and controllably release sandela 803. PPMM-PEG@S803 was then applied to wallpaper (PPMM-PEG-W@S803) and the effects of this treated wallpaper on CNS of mice were evaluated. The results showed that PPMM-PEG-W@S803 had excellent decompression effects and antianxiety effects. And the mechanisms of these effects maybe lie in the increases of neural activity in hippocampus, hypothalamus and olfactory bulb regions, the enhances of the abilities of nerve regeneration in olfactory bulb, corpus striatum and substantia nigra and the increases of the expressions of dopamine, acetylcholine, gamma-aminobutyric acid and N-methyl-D-aspartic acid. Besides, the effects were more significant as time progresses.

KeywordPhoto-activated Releasing Sandela 803 Ppmm-peg-w@s803 Central Nervous System Neural Activity Nerve Regeneration
DOI10.1166/jbn.2018.2611
Language英语
WOS KeywordElevated Plus-maze ; Thermosensitive Hydrogel ; Efficient Inhibition ; Substantia-nigra ; Olfactory-bulb ; Santalum-album ; Breast-cancer ; Cell-line ; Micelles ; Memory
Funding ProjectNational High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[2164071] ; the National Natural Science Foundation of China[31522023] ; the National Natural Science Foundation of China[51373177] ; the National Natural Science Foundation of China[51573188] ; Beijing Municipal Science and Technology Commission[Z161100002616015]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, bioMaterials
Funding OrganizationNational High Technology Research and Development Program ; Beijing Natural Science Foundation ; the National Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission
WOS IDWOS:000439760200001
PublisherAMER SCIENTIFIC PUBLISHERS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25508
Collection中国科学院过程工程研究所
Corresponding AuthorZheng, Yongchang; Zhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Liver Surg, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Beijing 100730, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
6.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
Recommended Citation
GB/T 7714
Lu, Zhiguo,Zheng, Yongchang,Zhang, Tianlu,et al. Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018,14(10):1675-1687.
APA Lu, Zhiguo.,Zheng, Yongchang.,Zhang, Tianlu.,Shen, Jie.,Xiao, Zuobing.,...&Zhang, Xin.(2018).Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,14(10),1675-1687.
MLA Lu, Zhiguo,et al."Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14.10(2018):1675-1687.
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