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Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly
Li, Shukun1,3; Zou, Qianli1; Li, Yongxin1,3; Yuan, Chengqian1; Xing, Ruirui1; Yan, Xuehai1,2,3
2018-08-29
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume140Issue:34Pages:10794-10802
Abstract

Supramolecular photosensitizer nanodrugs that combine the flexibility of supramolecular self-assembly and the advantage of spatiotemporal, controlled drug delivery are promising for dedicated, precise, noninvasive tumor therapy. However, integrating robust blood circulation and targeted burst release in a single photosensitizer nanodrug platform that can simultaneously improve the therapeutic performance and reduce side effects is challenging. Herein, we demonstrate a multicomponent coordination self-assembly strategy that is versatile and potent for the development of photodynamic nanodrugs. Inspired by the multicomponent self-organization of polypeptides, pigments, and metal ions in metalloproteins, smart metallo-nanodrugs are constructed based on the combination and cooperation of multiple coordination, hydrophobic, and electrostatic noncovalent interactions among short peptides, photosensitizers, and metal ions. The resulting metallo-nanodrugs have uniform sizes, well-defined nanosphere structures, and high loading capacities. Most importantly, multicomponent assembled nanodrugs have robust colloidal stability and ultrasensitive responses to pH and redox stimuli. These properties prolong blood circulation, increase tumor accumulation, and enhance the photodynamic tumor therapeutic efficacy. This study offers a new strategy to harness robust, smart metallo-nanodrugs with integrated flexibility and multifunction to enhance tumor-specific delivery and therapeutic effects, highlighting opportunities to develop next-generation, smart photosensitizing nanomedicines.

DOI10.1021/jacs.8b04912
Language英语
WOS KeywordDrug-delivery ; Crystal-structure ; Therapy ; Nanoparticles ; Protein ; Cells ; Ph ; Metalloproteins ; Conversion ; Chlorin
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21603233] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2017DE0004] ; CAS President's International Fellowship Initiative[2017VEA0023]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative
WOS IDWOS:000443654400027
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25879
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Shukun,Zou, Qianli,Li, Yongxin,et al. Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(34):10794-10802.
APA Li, Shukun,Zou, Qianli,Li, Yongxin,Yuan, Chengqian,Xing, Ruirui,&Yan, Xuehai.(2018).Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(34),10794-10802.
MLA Li, Shukun,et al."Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.34(2018):10794-10802.
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