CAS OpenIR
Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy
Zhang, Han1,2; Liu, Kai2,3,6; Li, Shukun2,3; Xin, Xia1,5; Yuan, Shiling1; Ma, Guanghui2; Yan, Xuehai2,3,4
2018-08-01
Source PublicationACS NANO
ISSN1936-0851
Volume12Issue:8Pages:8266-8276
Abstract

Minimalist multifunctional platforms for delivering diagnostic and therapeutic agents effectively and safely into tumor sites are highly desired in nanomedicine. Herein, we describe the fabrication of a supramolecular nanoplatform via the amphiphilic amino acid (9-fluorenylmethyloxycarbonyl-L-leucine, Fmoc-L-L)-modulated self-assembly of a magnetic resonance imaging (MRI) contrast agent (ionic manganese, Mn2+) and photosensitive drug (chlorin e6, Ce6). Coordination drives the coassembly of Fmoc-L-L and Mn2+ to generate a nanoscale supramolecular network to adaptively encapsulate Ce6. The obtained biometal-organic nanoparticles exhibit a high drug loading capability, inherent good biocompatibility, robust stability, and smart disassembly in response to glutathione (GSH). The cooperative assembly of the multiple components is synchronously dynamic in nature and enables enhanced photodynamic therapy (PDT) to damage tumor cells and tissue by efficiently delivering the photosensitizer and improving the reductive tumor microenvironment via the competitive coordination of GSH with Mn2+. The antitumor effect can also be monitored and evaluated in vivo by MRI through the long-term intracellular biochelation of Mn2+. Therefore, this work presents a one pot and robust method for the self-assembly of a multifunctional theranostic nanoplatform capable of MRI-guided PDT starting from minimalist biological building blocks.

KeywordSelf-assembly Amino Acid Nanoplatform Magnetic Resonance Imaging Photodynamic Therapy
DOI10.1021/acsnano.8b03529
Language英语
WOS KeywordMri Contrast Agents ; Cancer Theranostics ; Drug-delivery ; Nanoparticles ; Polymers ; Nanomaterials ; Platform ; Release ; Ions ; Nanomedicine
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[91434103] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences
WOS IDWOS:000443525600078
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25886
Collection中国科学院过程工程研究所
Corresponding AuthorXin, Xia; Yuan, Shiling; Yan, Xuehai
Affiliation1.Shandong Univ, Sch Chem & Chem Engn, Key Lab Colloid & Interface Chem, Educ Minist, Jinan 250100, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
5.Shandong Univ, Natl Engn Technol Res Ctr Colloidal Mat, Jinan 250100, Shandong, Peoples R China
6.Univ Groningen, Stratingh Inst, Ctr Syst Chem, NL-9747 AG Groningen, Netherlands
Recommended Citation
GB/T 7714
Zhang, Han,Liu, Kai,Li, Shukun,et al. Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy[J]. ACS NANO,2018,12(8):8266-8276.
APA Zhang, Han.,Liu, Kai.,Li, Shukun.,Xin, Xia.,Yuan, Shiling.,...&Yan, Xuehai.(2018).Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy.ACS NANO,12(8),8266-8276.
MLA Zhang, Han,et al."Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy".ACS NANO 12.8(2018):8266-8276.
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