CAS OpenIR
Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo
Li, Jieling1; Wang, Anhe1; Zhao, Luyang1; Dong, Qianqian1; Wang, Meiyue1; Xu, Haolan2; Yan, Xuehai1; Bai, Shuo1
2018-08-29
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号10期号:34页码:28420-28427
摘要Employing nanoscaled materials as photosensitizer (PS) carriers is an effective strategy to solve the problem of poor solubility and low tumor selectivity of hydrophobic PS in photodynamic therapy (PDT), which compulsorily requires the PS release in PDT implementation. However, the complicated environment in vivo makes it difficult to precisely design and control the release process and the delivery process requires real-time tracking. Developing a delivery strategy of hydrophobic PS in the monomeric form with fluorescent emission and without consideration of the PS release in the PDT process, is in urgent demand. Herein, we report a versatile and potent strategy for fabrication of photodynamic nanoparticles (nanoPSs) with featuring the monomeric PS based on aromatic peptide-modulated self-assembly of porphyrin derivatives. Aromatic peptides within nanoPSs can isolate hydrophobic porphyrins from each other, resulting in monomeric porphyrin delivery with real-time fluorescence tracking property and avoiding self-aggregation and hence porphyrin release. Moreover, partially charged porphyrins tend to expose on the surface of nanoPSs, facilitating production and diffusion of O-1(2). The highest O-1(2) yield can be achieved with porphyrin loading as low as 6 wt %, reducing side effects of excessive porphyrin injection. The nanoPSs show enhanced PDT efficacy in vitro and in vivo leading to complete tumor eradication. This study highlights opportunities for development of active photodynamic nanoparticles and provides an alternative strategy for delivery of hydrophobic photosensitive drugs with enhanced therapeutic effects.
关键词short peptide self-assembly photosensitizer photodynamic nanoparticles real-time tracking
DOI10.1021/acsami.8b09933
语种英语
关键词[WOS]CANCER-TREATMENT ; THERAPY ; NANOCAGES
资助项目National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21644007] ; National Natural Science Foundation of China[21473208] ; Talent Fund of the Recruitment Program of Global Youth Experts
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts
WOS记录号WOS:000443654600019
出版者AMER CHEMICAL SOC
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/25933
专题中国科学院过程工程研究所
通讯作者Yan, Xuehai; Bai, Shuo
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, 1 North Second St, Beijing 100190, Peoples R China
2.Univ South Australia Mawson Lakes, Future Ind Inst, Mawson Lakes, SA 5092, Australia
推荐引用方式
GB/T 7714
Li, Jieling,Wang, Anhe,Zhao, Luyang,et al. Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(34):28420-28427.
APA Li, Jieling.,Wang, Anhe.,Zhao, Luyang.,Dong, Qianqian.,Wang, Meiyue.,...&Bai, Shuo.(2018).Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo.ACS APPLIED MATERIALS & INTERFACES,10(34),28420-28427.
MLA Li, Jieling,et al."Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo".ACS APPLIED MATERIALS & INTERFACES 10.34(2018):28420-28427.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Jieling]的文章
[Wang, Anhe]的文章
[Zhao, Luyang]的文章
百度学术
百度学术中相似的文章
[Li, Jieling]的文章
[Wang, Anhe]的文章
[Zhao, Luyang]的文章
必应学术
必应学术中相似的文章
[Li, Jieling]的文章
[Wang, Anhe]的文章
[Zhao, Luyang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。