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Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo
Li, Jieling1; Wang, Anhe1; Zhao, Luyang1; Dong, Qianqian1; Wang, Meiyue1; Xu, Haolan2; Yan, Xuehai1; Bai, Shuo1
2018-08-29
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:34Pages:28420-28427
AbstractEmploying nanoscaled materials as photosensitizer (PS) carriers is an effective strategy to solve the problem of poor solubility and low tumor selectivity of hydrophobic PS in photodynamic therapy (PDT), which compulsorily requires the PS release in PDT implementation. However, the complicated environment in vivo makes it difficult to precisely design and control the release process and the delivery process requires real-time tracking. Developing a delivery strategy of hydrophobic PS in the monomeric form with fluorescent emission and without consideration of the PS release in the PDT process, is in urgent demand. Herein, we report a versatile and potent strategy for fabrication of photodynamic nanoparticles (nanoPSs) with featuring the monomeric PS based on aromatic peptide-modulated self-assembly of porphyrin derivatives. Aromatic peptides within nanoPSs can isolate hydrophobic porphyrins from each other, resulting in monomeric porphyrin delivery with real-time fluorescence tracking property and avoiding self-aggregation and hence porphyrin release. Moreover, partially charged porphyrins tend to expose on the surface of nanoPSs, facilitating production and diffusion of O-1(2). The highest O-1(2) yield can be achieved with porphyrin loading as low as 6 wt %, reducing side effects of excessive porphyrin injection. The nanoPSs show enhanced PDT efficacy in vitro and in vivo leading to complete tumor eradication. This study highlights opportunities for development of active photodynamic nanoparticles and provides an alternative strategy for delivery of hydrophobic photosensitive drugs with enhanced therapeutic effects.
Keywordshort peptide self-assembly photosensitizer photodynamic nanoparticles real-time tracking
DOI10.1021/acsami.8b09933
Language英语
WOS KeywordCANCER-TREATMENT ; THERAPY ; NANOCAGES
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21644007] ; National Natural Science Foundation of China[21473208] ; Talent Fund of the Recruitment Program of Global Youth Experts
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts
WOS IDWOS:000443654600019
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/25933
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai; Bai, Shuo
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, 1 North Second St, Beijing 100190, Peoples R China
2.Univ South Australia Mawson Lakes, Future Ind Inst, Mawson Lakes, SA 5092, Australia
Recommended Citation
GB/T 7714
Li, Jieling,Wang, Anhe,Zhao, Luyang,et al. Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(34):28420-28427.
APA Li, Jieling.,Wang, Anhe.,Zhao, Luyang.,Dong, Qianqian.,Wang, Meiyue.,...&Bai, Shuo.(2018).Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo.ACS APPLIED MATERIALS & INTERFACES,10(34),28420-28427.
MLA Li, Jieling,et al."Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo".ACS APPLIED MATERIALS & INTERFACES 10.34(2018):28420-28427.
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