CAS OpenIR
Delivery systems for theranostics in neurodegenerative diseases
Li, Yan1; Liu, Ruiyuan1,2; Ji, Weihong1,2; Li, Yanhui1; Liu, Linying1,2; Zhang, Xin1
2018-10-01
Source PublicationNANO RESEARCH
ISSN1998-0124
Volume11Issue:10Pages:5535-5555
Abstract

Neurodegenerative diseases are characterized by progressive nervous system dysfunction, which affects over 90,000 people every year. Although numerous contrast agents and therapeutic drugs are available for the diagnosis and therapy of neurodegenerative diseases, there are several limitations to their application. Particularly, these contrast agents and drugs are restricted from entering into the brain because of the blood-brain barrier, which represents a major bottleneck to efficacious and safe theranostics of neurodegenerative diseases. Nanoparticles can offer impressive improvement in the theranostics of neurodegenerative diseases, as they can effectively deliver contrast agents and drugs to target sites in the central nervous system. In this review, we describe various delivery systems, including lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and exosomes useful for the theranostics of neurodegenerative diseases. Finally, we outline current challenges and our perspectives on the development of delivery systems for theranostics of neurodegenerative diseases.

KeywordNeurodegenerative Diseases Theranostics Blood-brain Barrier Delivery Systems
DOI10.1007/s12274-018-2067-z
Language英语
WOS KeywordSolid Lipid Nanoparticles ; Blood-brain-barrier ; Dual-functional Nanoparticles ; Beta-amyloid Aggregation ; Alzheimers-disease ; Parkinsons-disease ; Drug-delivery ; Alpha-synuclein ; Sirna Delivery ; Magnetic Nanoparticles
Funding ProjectNational High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046] ; National Natural Science Foundation of China[31522023] ; National Natural Science Foundation of China[51373177] ; National Natural Science Foundation of China[51573188] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Chinese Academy of Sciences[XDA09030301-3]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; Chinese Academy of Sciences
WOS IDWOS:000446423900029
PublisherTSINGHUA UNIV PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/26214
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Yan,Liu, Ruiyuan,Ji, Weihong,et al. Delivery systems for theranostics in neurodegenerative diseases[J]. NANO RESEARCH,2018,11(10):5535-5555.
APA Li, Yan,Liu, Ruiyuan,Ji, Weihong,Li, Yanhui,Liu, Linying,&Zhang, Xin.(2018).Delivery systems for theranostics in neurodegenerative diseases.NANO RESEARCH,11(10),5535-5555.
MLA Li, Yan,et al."Delivery systems for theranostics in neurodegenerative diseases".NANO RESEARCH 11.10(2018):5535-5555.
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