CAS OpenIR
"Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway
Li, YanHui1,2; Chen, ZiXuan1; Lu, ZhiGuo2; Yang, QingHu1; Liu, LinYing2; Jiang, ZhaoTan1; Zhang, LiQun3; Zhang, Xin2; Qing, Hong1
2018
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume8Issue:19Pages:5469-5481
Abstract

alpha-synclein (aS) aggregation is a representative molecular feature of the pathogenesis of Parkinson's disease (PD). Epigallocatechin gallate (EGCG) can prevent alpha S aggregation in vitro. However, the in vivo effects of PD treatment are poor due to the obstacles of EGCG accumulation in dopaminergic neurons, such as the blood brain barrier and high binding affinities between EGCG and membrane proteins. Therefore, the key to PD treatment lies in visual examination of EGCG accumulation in dopaminergic neurons. Methods: DSPE-PEG-B6, DSPE-PEG-MA, DSPE-PEG-phenylboronic acid, and superparamagnetic iron oxide nanocubes were self-assembled into tracing nanoparticles (NPs). EGCG was then conjugated on the surface of the NPs through the formation of boronate ester bonds to form a "cell-addictive" dual-target traceable nanodrug (B6ME-NPs). B6ME-NPs were then used for PD treatment via intravenous injection. Results: After treatment with B6ME-NPs, the PD-like characteristics was alleviated significantly. First, the amount of EGCG accumulation in PD lesions was markedly enhanced and traced via magnetic resonance imaging. Further, alpha S aggregation was greatly inhibited. Finally, the dopaminergic neurons were considerably increased. Conclusion: Due to their low price, simple preparation, safety, and excellent therapeutic effect on PD, B6ME-NPs are expected to have potential application in PD treatment.

KeywordParkinson's Disease Dopaminergic Neurons Egcg Nanoparticles Alpha-synclein Aggregation
DOI10.7150/thno.28295
Language英语
WOS KeywordBlood-brain-barrier ; Cocaine Binding-site ; Alpha-synuclein ; Dopamine Transporter ; Laminin Receptor ; Tea Polyphenol ; Potential Inhibitors ; Alzheimers-disease ; Mazindol Analogs ; Delivery
Funding ProjectBeijing Municipal Science & Technology Commission[Z161100002616015] ; National Natural Science Foundation of China[81671268] ; National Natural Science Foundation of China[81701260] ; Brain cognition and brain medicine of Beijing Municipal Science & Technology Commission[Z161100002616020] ; National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046]
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
Funding OrganizationBeijing Municipal Science & Technology Commission ; National Natural Science Foundation of China ; Brain cognition and brain medicine of Beijing Municipal Science & Technology Commission ; National High Technology Research and Development Program ; Beijing Natural Science Foundation
WOS IDWOS:000450037900018
PublisherIVYSPRING INT PUBL
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/26542
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin; Qing, Hong
Affiliation1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Capital Med Univ, Beijing Chest Hosp, Beijing 101149, Peoples R China
Recommended Citation
GB/T 7714
Li, YanHui,Chen, ZiXuan,Lu, ZhiGuo,et al. "Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway[J]. THERANOSTICS,2018,8(19):5469-5481.
APA Li, YanHui.,Chen, ZiXuan.,Lu, ZhiGuo.,Yang, QingHu.,Liu, LinYing.,...&Qing, Hong.(2018)."Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.THERANOSTICS,8(19),5469-5481.
MLA Li, YanHui,et al.""Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway".THERANOSTICS 8.19(2018):5469-5481.
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