CAS OpenIR
Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy
Liu, Yamei1,2,4; Zhao, Luyang2; Xing, Ruirui2; Jiao, Tifeng1,4; Song, Weixing3; Yan, Xuehai2
2018-11-16
Source PublicationCHEMISTRY-AN ASIAN JOURNAL
ISSN1861-4728
Volume13Issue:22Pages:3526-3532
Abstract

Organic photothermal sensitizers, such as indocyanine green (ICG), have been widely explored in photothermal therapy as a good substitute for inorganic materials owing to their advantageous biosafety and strong absorption in the near-infrared region. However, their intrinsic low stability and rapid clearance from the body requires further modification for efficient therapeutic application. In this work, we employed a covalent assembly strategy by covalently cross-linking genipin and a functional bola-amino acid to fabricate stable and degradable nanoparticles capable of loading ICG. The covalent assembly introduced strong covalent interactions in the assembly system together with functional linkers, which led to both enhanced stability and extended functionalities. This is distinguished from the conventional supramolecular strategy that relies only on weak noncovalent interactions. The functional building unit, consisting of phenylalanine and the disulfide bond, enables both good assembly and controllable degradation owing to the disulfide bond that responds to glutathione. The assembled nanoparticles show high stability, negligible toxicity, and considerable biodegradability. After loading ICG, the ICG-loaded nanoparticles possessed high photothermal conversion efficiency, and showed an enhanced photothermal effect in the near-infrared region. This covalent assembly strategy could be extended to various biomolecules containing a primary amino group for the fabrication of efficient and multifunctional nanomaterials used in biomedical applications.

KeywordAmino Acids Drug Delivery Nanostructures Photothermal Effect Self-assembly
DOI10.1002/asia.201800825
Language英语
WOS KeywordDipeptide-based Nanocarriers ; Guided Oncologic Surgery ; Photodynamic Therapy ; Indocyanine Green ; Drug-delivery ; Cancer-cells ; Nanoarchitectonics ; Systems ; Light ; Photosensitizers
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[2170325] ; National Natural Science Foundation of China[21473208] ; China Postdoctoral Science Foundation[2017M610113] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2017DE0004] ; CAS President's International Fellowship Initiative[2017VEA0023]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative
WOS IDWOS:000450362500020
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/26589
Collection中国科学院过程工程研究所
Corresponding AuthorJiao, Tifeng; Song, Weixing; Yan, Xuehai
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China
4.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yamei,Zhao, Luyang,Xing, Ruirui,et al. Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy[J]. CHEMISTRY-AN ASIAN JOURNAL,2018,13(22):3526-3532.
APA Liu, Yamei,Zhao, Luyang,Xing, Ruirui,Jiao, Tifeng,Song, Weixing,&Yan, Xuehai.(2018).Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy.CHEMISTRY-AN ASIAN JOURNAL,13(22),3526-3532.
MLA Liu, Yamei,et al."Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy".CHEMISTRY-AN ASIAN JOURNAL 13.22(2018):3526-3532.
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