CAS OpenIR
Amplifying Nanoparticle Targeting Performance to Tumor via Diels-Alder Cycloaddition
Lu, GH; Li, F; Zhang, F; Huang, LL; Zhang, LJ; Lv, YL; Wei, W; Xie, HY; Lu, Guihong; Li, Feng; Zhang, Fan; Huang, Li-Li; Zhang, Lijun; Lv, Yanlin; Wei, Wei; Xie, Hai-Yan
2018
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume28Issue:30
Abstract

Traditional targeting approach utilizing biological ligands has to face the problems of limited receptors and tumor heterogeneity. Herein, a two-step tumor-targeting and therapy strategy based on inverse electron-demand [4+2] Diels-Alder cycloaddition (iEDDA) is described. Owing to the unique acidic tumor microenvironment, an intravenous injection of tetrazine modified pH (low) insertion peptide could efficiently target and incorporate onto various cell surfaces in tumor tissue, such as cancer cells, vascular endothelial cells, and tumor-associated fibroblasts. The receptor-like tetrazine groups with a large amount and homogeneous intratumoral distribution could then serve as the baits to greatly amplify the tumor-targeting ability of indocyanine green (ICG)-loaded and trans-cyclooctene (TCO)-conjugated human serum albumin (HSA) nanoparticles (TCO-HSA-ICG NPs) via iEDDA after the second intravenous injection. Compared with the passive enhanced permeability and retention (EPR) effect and traditional active targeting approaches, the targeting performance and photothermal therapeutic effect based on the two-step strategy are significantly enhanced, while no notable toxicity is observed. As acidity is a characteristic of solid tumor, the two-step strategy can serve as a universal and promising modality for safe and high-performance nanoparticle-based antitumor therapy.

KeywordDiels-alder Cycloaddition 808-nm Diode-laser Ph (Low) Insertion Peptide In-vivo Photothermal Therapy Click Chemistry Tumor Targeting Drug-delivery Two-step Strategy Bioorthogonal Chemistry Indocyanine Green Cancer Heterogeneity Therapy Peptide
SubtypeArticle
DOI10.1002/adfm.201707596
WOS IDWOS:000439738200003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/26686
Collection中国科学院过程工程研究所
Recommended Citation
GB/T 7714
Lu, GH,Li, F,Zhang, F,et al. Amplifying Nanoparticle Targeting Performance to Tumor via Diels-Alder Cycloaddition[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(30).
APA Lu, GH.,Li, F.,Zhang, F.,Huang, LL.,Zhang, LJ.,...&Xie, Hai-Yan.(2018).Amplifying Nanoparticle Targeting Performance to Tumor via Diels-Alder Cycloaddition.ADVANCED FUNCTIONAL MATERIALS,28(30).
MLA Lu, GH,et al."Amplifying Nanoparticle Targeting Performance to Tumor via Diels-Alder Cycloaddition".ADVANCED FUNCTIONAL MATERIALS 28.30(2018).
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