CAS OpenIR
Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway
Li, YH; Chen, ZX; Lu, ZG; Yang, QH; Liu, LY; Jiang, ZT; Zhang, LQ; Zhang, X; Qing, H; Li, YanHui; Chen, ZiXuan; Lu, ZhiGuo; Yang, QingHu; Liu, LinYing; Jiang, ZhaoTan; Zhang, LiQun; Zhang, Xin; Qing, Hong
2018
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume8Issue:19Pages:5469
Abstract

alpha-synclein (aS) aggregation is a representative molecular feature of the pathogenesis of Parkinson's disease (PD). Epigallocatechin gallate (EGCG) can prevent alpha S aggregation in vitro. However, the in vivo effects of PD treatment are poor due to the obstacles of EGCG accumulation in dopaminergic neurons, such as the blood brain barrier and high binding affinities between EGCG and membrane proteins. Therefore, the key to PD treatment lies in visual examination of EGCG accumulation in dopaminergic neurons. Methods: DSPE-PEG-B6, DSPE-PEG-MA, DSPE-PEG-phenylboronic acid, and superparamagnetic iron oxide nanocubes were self-assembled into tracing nanoparticles (NPs). EGCG was then conjugated on the surface of the NPs through the formation of boronate ester bonds to form a "cell-addictive" dual-target traceable nanodrug (B6ME-NPs). B6ME-NPs were then used for PD treatment via intravenous injection. Results: After treatment with B6ME-NPs, the PD-like characteristics was alleviated significantly. First, the amount of EGCG accumulation in PD lesions was markedly enhanced and traced via magnetic resonance imaging. Further, alpha S aggregation was greatly inhibited. Finally, the dopaminergic neurons were considerably increased. Conclusion: Due to their low price, simple preparation, safety, and excellent therapeutic effect on PD, B6ME-NPs are expected to have potential application in PD treatment.

Other Abstract

This work was financially supported by the Beijing Municipal Science & Technology Commission (No. Z161100002616015), National Natural Science Foundation of China (No. 81671268), the Brain cognition and brain medicine of Beijing Municipal Science & Technology Commission (Z161100002616020), the National natural science foundation of China (81701260), the National High Technology Research and Development Program (2016YFA0200303) and the Beijing Natural Science Foundation (L172046).

KeywordParkinson's Disease Blood-brain-barrier Dopaminergic Neurons Cocaine Binding-site Egcg Alpha-synuclein Nanoparticles Dopamine Transporter Alpha-synclein Aggregation Laminin Receptor Tea Polyphenol Potential Inhibitors Alzheimers-disease Mazindol Analogs Delivery
SubtypeArticle
DOI10.7150/thno.28295
Funding OrganizationBeijing Municipal Science & Technology Commission [Z161100002616015] ; National Natural Science Foundation of China [81671268, 81701260] ; Brain cognition and brain medicine of Beijing Municipal Science & Technology Commission [Z161100002616020] ; National High Technology Research and Development Program [2016YFA0200303] ; Beijing Natural Science Foundation [L172046]
WOS IDWOS:000450037900018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/26823
Collection中国科学院过程工程研究所
Recommended Citation
GB/T 7714
Li, YH,Chen, ZX,Lu, ZG,et al. Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway[J]. THERANOSTICS,2018,8(19):5469.
APA Li, YH.,Chen, ZX.,Lu, ZG.,Yang, QH.,Liu, LY.,...&Qing, Hong.(2018).Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway.THERANOSTICS,8(19),5469.
MLA Li, YH,et al."Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway".THERANOSTICS 8.19(2018):5469.
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