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Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging
Alternative TitleColloid Surf. A-Physicochem. Eng. Asp.
Feng, B.1,2; Hong, R. Y.1,2,3; Wang, L. S.1,2; Guo, L.4; Li, H. Z.3; Ding, J.5; Zheng, Y.6; Wei, D. G.7
2008-10-01
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume328Issue:1-3Pages:52-59
AbstractThe magnetite (Fe3O4) nanoparticles (MNPs) coated with PEG diacid via covalent bonds were prepared for magnetic resonance imaging (MRI). The surface of MNPs was first coated with (3-aminopropyl) tri-ethoxysilane (APITES) by a silanization reaction and then linked with PEG diacid via the reaction between -NH2 and -COOH to form well-dispersed surface functionalized biocompatible MNPs. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetry (TG). The MNPs had an average size of 20 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. In addition, PEG-6000 diacid coated Fe3O4 nanoparticles were used to perform the MRI experiments on the living rabbits with VX2 malignant tumor, the results showed that these nanoparticles appear to be a promising vehicle for MR imaging. (C) 2008 Elsevier B.V. All rights reserved.; The magnetite (Fe3O4) nanoparticles (MNPs) coated with PEG diacid via covalent bonds were prepared for magnetic resonance imaging (MRI). The surface of MNPs was first coated with (3-aminopropyl) tri-ethoxysilane (APITES) by a silanization reaction and then linked with PEG diacid via the reaction between -NH2 and -COOH to form well-dispersed surface functionalized biocompatible MNPs. The obtained nanoparticles were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetry (TG). The MNPs had an average size of 20 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. In addition, PEG-6000 diacid coated Fe3O4 nanoparticles were used to perform the MRI experiments on the living rabbits with VX2 malignant tumor, the results showed that these nanoparticles appear to be a promising vehicle for MR imaging. (C) 2008 Elsevier B.V. All rights reserved.
KeywordMagnetite Nanoparticle (Mnps) Peg Diacid Magnetic Fluids (Mfs) Magnetic Resonance Imaging (Mri)
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2008.06.024
URL查看原文
Indexed BySCI
Language英语
WOS KeywordFE3O4 NANOPARTICLES ; CONTRAST AGENTS ; DRUG-DELIVERY ; RESONANCE ; NANOCRYSTALS ; HYPERTHERMIA ; GADOLINIUM ; GROWTH ; CANCER ; CELLS
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000260205000009
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Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/2748
Collection研究所(批量导入)
Affiliation1.Soochow Univ, Dept Chem Engn, SIP, Suzhou 215123, Peoples R China
2.Soochow Univ, Key Lab Organ Synth Jiangsu Prov, SIP, Suzhou 215123, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase React, Beijing 100080, Peoples R China
4.Soochow Univ, Affiliated Hosp 1, MRI Div, Suzhou 215007, Peoples R China
5.IBM Corp, Rochester, MN 55901 USA
6.Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada
7.Harvard Univ, Sch Engn & Appl Sci, Ctr Nanoscale Syst, Cambridge, MA 02139 USA
Recommended Citation
GB/T 7714
Feng, B.,Hong, R. Y.,Wang, L. S.,et al. Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2008,328(1-3):52-59.
APA Feng, B..,Hong, R. Y..,Wang, L. S..,Guo, L..,Li, H. Z..,...&Wei, D. G..(2008).Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,328(1-3),52-59.
MLA Feng, B.,et al."Synthesis of Fe3O4/APTES/PEG diacid functionalized magnetic nanoparticles for MR imaging".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 328.1-3(2008):52-59.
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