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Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease
Zhang, Li-fan1,2; Yu, Xiao-lin1; Ji, Mei1; Liu, Shu-ying1; Wu, Xiao-ling2; Wang, Yu-jiong2; Liu, Rui-tian1
2018-12-01
Source PublicationFOOD & FUNCTION
ISSN2042-6496
Volume9Issue:12Pages:6415-6427
Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by Lewy pathology and progressive loss of dopaminergic neurons in the substantia nigra. Lewy pathology mainly consists of abnormal aggregates of -synuclein, which play a pivotal role in PD pathophysiology. However, the complexity of PD leads to clinical challenges, and there are still no treatments to halt or slow the neurodegenerative process. Resveratrol (RV) is a natural polyphenol compound with multiple biological activities, which has been reported to exert neuroprotective effects on several neurological diseases. Here we first provided evidence that RV treatment alleviated motor and cognitive deficits in the A53T -synuclein mouse model of PD in a dose-dependent manner. The beneficial effects of RV against PD resulted from inhibiting -synuclein aggregation and cytotoxicity, lowering the levels of total -synuclein and oligomers, reducing neuroinflammation and oxidative stress. These findings suggest that RV has promising therapeutic potential for PD and other synucleinopathies.

DOI10.1039/c8fo00964c
Language英语
WOS KeywordAlpha-synuclein Oligomers ; Oxidative Stress ; Neuroprotective Action ; Induced Neurotoxicity ; Neuroinflammation ; Bioavailability ; Metaanalysis ; Polyphenols ; Mechanisms ; Microglia
Funding ProjectNational Science and Technology Major Projects of New Drugs[2018ZX09301032] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDA12040215]
WOS Research AreaBiochemistry & Molecular Biology ; Food Science & Technology
WOS SubjectBiochemistry & Molecular Biology ; Food Science & Technology
Funding OrganizationNational Science and Technology Major Projects of New Drugs ; Strategic Priority Research Program of Chinese Academy of Sciences
WOS IDWOS:000453244900031
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27593
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Yu-jiong; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Ningxia Univ, Key Lab, Minist Educ Protect & Utilizat Special Biol Sourc, Yinchuan 750021, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Li-fan,Yu, Xiao-lin,Ji, Mei,et al. Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease[J]. FOOD & FUNCTION,2018,9(12):6415-6427.
APA Zhang, Li-fan.,Yu, Xiao-lin.,Ji, Mei.,Liu, Shu-ying.,Wu, Xiao-ling.,...&Liu, Rui-tian.(2018).Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease.FOOD & FUNCTION,9(12),6415-6427.
MLA Zhang, Li-fan,et al."Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease".FOOD & FUNCTION 9.12(2018):6415-6427.
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