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Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice
Yuan, Xubing1,2,3; Zheng, Junping1,2,3; Ren, Lishi1,2; Jiao, Siming1,2; Feng, Cui1,2; Du, Yuguang1,2; Liu, Hongtao1,2
2019-02-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume206Pages:403-411
AbstractThe polysaccharides of Enteromorpha prolifera (PEP) displayed various bioactivities such as anti-viral, anti-inflammatory and immune-regulative effects. However, no studies were performed on the biological effect of Enteromorpha prolifera oligomers (EPO). In this study, we prepared EPO and evaluated their anti-diabetic effect By enzymatic degradation, EPO were produced from PEP, and the average molecular weight was identified to be 44.1 kDa by Gel Permeation Chromatography (GPC) analysis. The major monosaccharide units of EPO were measured to be rhamnose, glucuronic acid, glucose, xylose and galactose by capillary electrophoresis assay. Based on the in vitro studies, EPO presented potent reducing power and antioxidant effect such as the scavenging of 1, 1-dipheny1-2-picrylhydrazyl (DPPH), superoxide and NO radicals. The in vivo studies show that EPO relieved the symptoms of polydipsia, polyphagia, emaciation and hyperglycemia in streptozotocin (STZ)-induced diabetic mice to a certain extent Further, by using the quantitative real-time PCR (qPCR) assay and immuno-fluorescence staining, EPO was proved to promote the insulin secretion by reducing pancreatic inflammation and apoptosis in diabetic mice. In summary, our results indicate that the mitigation of EPO on pancreatic damage might be an effective way to ameliorate the diabetes mellitus.
KeywordEnteromorpha prolifera oligomers Antioxidation Diabetes mellitus Inflammation Apoptosis
DOI10.1016/j.carbpol.2018.11.019
Language英语
WOS KeywordIN-VITRO ANTIOXIDANT ; SULFATED POLYSACCHARIDES ; DEGRADED POLYSACCHARIDES ; PURIFICATION ; INFLAMMATION ; EXTRACTION ; LINZA
Funding ProjectNational Natural Science Foundation Of China[31570801] ; National Natural Science Foundation Of China[31500747]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational Natural Science Foundation Of China
WOS IDWOS:000452982700046
PublisherELSEVIER SCI LTD
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27614
Collection中国科学院过程工程研究所
Corresponding AuthorDu, Yuguang; Liu, Hongtao
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xubing,Zheng, Junping,Ren, Lishi,et al. Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice[J]. CARBOHYDRATE POLYMERS,2019,206:403-411.
APA Yuan, Xubing.,Zheng, Junping.,Ren, Lishi.,Jiao, Siming.,Feng, Cui.,...&Liu, Hongtao.(2019).Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice.CARBOHYDRATE POLYMERS,206,403-411.
MLA Yuan, Xubing,et al."Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice".CARBOHYDRATE POLYMERS 206(2019):403-411.
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