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Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents
Feng, Mi1,2; Lu, Xingmei1,2; Zhang, Jie2; Li, Yi3; Shi, Chunyan2; Lu, Lingling3; Zhang, Suojiang1,2
2019-01-07
Source PublicationGREEN CHEMISTRY
ISSN1463-9262
Volume21Issue:1Pages:87-98
AbstractTo obtain O-acylated chitin from shrimp shells directly, the used solvent should have multiple functions to remove calcium carbonate, protein, and acylated chitin. Herein, we use the acidic natural deep eutectic solvents (NADESs) with the ability to release H+ and various hydrogen bonding sites to achieve the above goal. The involved NADESs with three abilities of decalcification, deproteinization and acylation replaced acids, alkalis, catalysts, and acylation reagents in the conventional method. The experimental results revealed that the components of the NADESs, experiment temperature and time played key roles in the purity and degree of substitution (DS) of O-acylated chitin. Meanwhile, the ratio of shrimp shells to NADESs and a small amount of water had little effect on the preparation of O-acylated chitin. With the optimal NADES (choline chloride/dl-malic acid 1:2, ChCl 1-dl Mal 2) treatment under the optimal conditions, the purity of O-malate chitin reached 98.6% with a DS of 0.46, exhibiting antibacterial and anti-tumor effects. The experimental results showed that the removal of calcium carbonate and protein and acylation of chitin were carried out simultaneously. Mechanistic exploration using spectroscopy and experiments confirmed that H+ release from ChCl 1-dl Mal 2 was the main reason for the removal of calcium carbonate and initiation acylation reaction. The protein was degraded to amino acids because of the acidity of ChCl 1-dl Mal 2 and dissolved in the NADES due to hydrogen bonding formation with ChCl 1-dl Mal 2.
DOI10.1039/c8gc02506a
Language英语
WOS KeywordCHOLINE CHLORIDE ; AQUEOUS-SOLUTION ; LOBSTER SHELLS ; IONIC LIQUIDS ; HIGH-PURITY ; CHITOSAN ; EXTRACTION ; WASTE ; DERIVATIVES ; WATER
Funding ProjectNational Basic Research Program of China (973 Program)[2015CB251401] ; Natural Scientific Fund of China[21476234] ; Natural Scientific Fund of China[21506231] ; National CAS/SAFEA International Partnership Program for Creative Research Teams[20140491518] ; Key Research Program of Frontier Sciences CAS[QYZDY-SSW-JSC011]
WOS Research AreaChemistry ; Science & Technology - Other Topics
WOS SubjectChemistry, Multidisciplinary ; Green & Sustainable Science & Technology
Funding OrganizationNational Basic Research Program of China (973 Program) ; Natural Scientific Fund of China ; National CAS/SAFEA International Partnership Program for Creative Research Teams ; Key Research Program of Frontier Sciences CAS
WOS IDWOS:000454943500008
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27699
Collection中国科学院过程工程研究所
Corresponding AuthorLu, Xingmei; Zhang, Suojiang
Affiliation1.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, CAS Key Lab Green Proc & Engn,Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Engn, Beijing 100049, Peoples R China
3.Capital Med Univ, Beijing Ctr Neural Regenerat & Repair, Key Lab Neurodegenerat Dis,Beijing Inst Brain Dis, Ctr Parkinsons Dis,Dept Neurobiol,Minist Educ, Beijing 100054, Peoples R China
Recommended Citation
GB/T 7714
Feng, Mi,Lu, Xingmei,Zhang, Jie,et al. Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents[J]. GREEN CHEMISTRY,2019,21(1):87-98.
APA Feng, Mi.,Lu, Xingmei.,Zhang, Jie.,Li, Yi.,Shi, Chunyan.,...&Zhang, Suojiang.(2019).Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents.GREEN CHEMISTRY,21(1),87-98.
MLA Feng, Mi,et al."Direct conversion of shrimp shells to O-acylated chitin with antibacterial and anti-tumor effects by natural deep eutectic solvents".GREEN CHEMISTRY 21.1(2019):87-98.
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