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Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin
Li, Yongxin1,3; Zou, Qianli1; Yuan, Chengqian1; Li, Shukun1,3; Xing, Ruirui1; Yan, Xuehai1,2,3
2018-12-21
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:52Pages:17084-17088
Abstract

Clinical translation of curcumin has been highly obstructed by the rapid degradation and poor tissue absorption of this agent. Herein, we report on the generation of supramolecular curcumin nanoagents through amino acid coordination driven self-assembly to simultaneously increase the biological stability and tumor accumulation of curcumin. The biological stability of curcumin was significantly improved both through coordination and through molecular stacking. The sizes of these nanoagents can be readily manipulated to facilitate tumor accumulation. These favorable therapeutic features, together with high drug-loading capacities and responses to pH and redox stimuli, substantially enhanced the antitumor activity of curcumin without discernible side effects. Hence, supramolecular curcumin nanoagents may hold promise in moving forward the clinical application of curcumin as an effective anticancer drug.

KeywordAmino Acids Antitumor Therapy Biological Stability Curcumin Self-assembly
DOI10.1002/anie.201810087
Language英语
WOS KeywordMetal-complexes ; Delivery ; Nanoarchitectonics ; Strategies ; Chemistry ; Systems ; Design ; Switch ; Cells ; Ph
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21603233] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative
WOS IDWOS:000454575500024
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27705
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Yongxin,Zou, Qianli,Yuan, Chengqian,et al. Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(52):17084-17088.
APA Li, Yongxin,Zou, Qianli,Yuan, Chengqian,Li, Shukun,Xing, Ruirui,&Yan, Xuehai.(2018).Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(52),17084-17088.
MLA Li, Yongxin,et al."Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.52(2018):17084-17088.
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