CAS OpenIR
Nanolongan with Multiple On-Demand Conversions for Ferroptosis-Apoptosis Combined Anticancer Therapy
Bao, Weier1,2,3; Liu, Xianwu1,2,3; Lv, Yanlin2; Lu, Gui-Hong2; Li, Feng2; Zhang, Fan2; Liu, Bin1; Li, Dan1; Wei, Wei2; Li, Yuan1
2019
Source PublicationACS NANO
ISSN1936-0851
Volume13Issue:1Pages:260-273
Abstract

As a type of programmed cell death, ferroptosis is distinct from apoptosis. The combination of the two thus provides a promising modality with which to significantly improve anticancer treatment efficacy. To fully utilize this combination, we herein designed a nanolongan delivery system, which possessed a typical structure of one core (up-conversion nanoparticles, UCNP) in one gel particle (Fe3+ cross-linked oxidized starch) with multiple on-demand conversions. The charge conversion of the nanolongan surface in a slightly acidic microenvironment enhanced circulation time for utilizing the enhanced permeability and retention effect, enabled efficient uptake by tumor cells, and induced subsequently lysosomal escape. As the core component, the UCNP with light conversion from near-infrared light to ultraviolet impediment of limited penetration depth and enabled the reduction of Fe3+ to Fe2+. Accordingly, gel networks of nanolongan could be deconstructed due to this valence conversion, leading to the rapid release of Fe2+ and doxorubicin (Dox). In this case, the Fenton reaction between Fe2+ and intracellular H2O2 generated potent reactive oxygen species for ferroptosis, while the co-released Dox penetrated into nucleus and induced apoptosis in a synergistic way. As a result, superior anticancer therapeutic effects were achieved with little systemic toxicity, indicating that our nanolongan could serve as a safe and high-performance platform for ferroptosis apoptosis combined anticancer therapy.

KeywordNanolongan Multiple On-demand Responsive Nir-responsive Ferroptosis Anticancer Combined Therapy
DOI10.1021/acsnano.8b05602
Language英语
WOS KeywordProlonged Circulation ; Enhanced Permeability ; Nanoparticles ; Chemotherapy ; Cell ; Combination ; Trastuzumab ; Transition ; Insights ; Design
Funding ProjectNational Natural Science Foundation of China[31471577] ; National Natural Science Foundation of China[31772014] ; National Natural Science Foundation of China[21622608] ; National Key R&D Program of China[2017YFA0207900]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China
WOS IDWOS:000456749900026
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27816
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Li, Yuan
Affiliation1.China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Key Lab Funct Dairy, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Bao, Weier,Liu, Xianwu,Lv, Yanlin,et al. Nanolongan with Multiple On-Demand Conversions for Ferroptosis-Apoptosis Combined Anticancer Therapy[J]. ACS NANO,2019,13(1):260-273.
APA Bao, Weier.,Liu, Xianwu.,Lv, Yanlin.,Lu, Gui-Hong.,Li, Feng.,...&Li, Yuan.(2019).Nanolongan with Multiple On-Demand Conversions for Ferroptosis-Apoptosis Combined Anticancer Therapy.ACS NANO,13(1),260-273.
MLA Bao, Weier,et al."Nanolongan with Multiple On-Demand Conversions for Ferroptosis-Apoptosis Combined Anticancer Therapy".ACS NANO 13.1(2019):260-273.
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