CAS OpenIR
Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %
Wang, Anhe; Li, Jieling; Dong, Qianqian; Wang, Shengtao; Jian, Honglei; Wang, Meiyue; Ren, Peng; Bai, Shuo
2019-01-30
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:4Pages:4408-4415
AbstractMicrogel loading with inorganic nanoparticle (NP) composites attracts interest for various biomedical applications. However, the encapsulation of NPs into microgels usually is a diffusion process driven by osmotic pressure, which depends highly on the concentration of NPs and causes low loading efficiency. In this work, we demonstrate preparation of microgels with ultrahigh content of various nano-objects (up to 92%, wt %) by a gelatin "casting" strategy using porous CaCO3 particles as templates. This approach could encapsulate various NPs with different charged, hydrophilic, and hydrophobic surfaces, shape, and size within microgels, without causing aggregation or change of physicochemical properties of NPs. The hybrid microgels coupled with properties of both inorganic NPs and hydrogels can be taken as an effective photothermal therapy system with great stability, reusability, and degradability and show high effective photothermal activity which is highly related to the content of NPs within microgels. The strategy of fabrication of microgels with nanocomposites is certified to be simple, facile, and low cost, which has potential applications in cancer therapy, drug delivery, catalysis, detecting system, and sewage treatment.
Keywordmicrogel encapsulation high payload nanocomposites "casting" strategy
DOI10.1021/acsami.8b20089
Language英语
WOS KeywordGOLD NANOPARTICLES ; CONTROLLED-RELEASE ; HYBRID MICROGELS ; AQUEOUS-MEDIA ; QUANTUM DOTS ; NANORODS ; GELATIN ; GLUCOSE ; MICROCAPSULES ; FABRICATION
Funding ProjectNational Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000457816900082
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27844
Collection中国科学院过程工程研究所
Corresponding AuthorBai, Shuo
AffiliationChinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Anhe,Li, Jieling,Dong, Qianqian,et al. Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(4):4408-4415.
APA Wang, Anhe.,Li, Jieling.,Dong, Qianqian.,Wang, Shengtao.,Jian, Honglei.,...&Bai, Shuo.(2019).Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %.ACS APPLIED MATERIALS & INTERFACES,11(4),4408-4415.
MLA Wang, Anhe,et al."Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %".ACS APPLIED MATERIALS & INTERFACES 11.4(2019):4408-4415.
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