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An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes
Zhu, Anlian1; Li, Lingjun1; Zhang, Chi1; Shen, Yutan1; Tang, Mingjie1; Bai, Lili1; Du, Chunyan1; Zhang, Suojiang2; Wang, Jianji1
2019-01-21
Source PublicationGREEN CHEMISTRY
ISSN1463-9262
Volume21Issue:2Pages:307-313
Abstract

Development of new chemical processes with simplified reaction systems and work-up procedures is a challenging task. Although ionic liquids are a class of potential multifunctional compounds to simplify traditional chemical processes, their rational design is difficult due to complex interactions. In this work, a proof-of-concept strategy has been proposed to achieve an integration of high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonylazide cycloaddition reactions. Merits of the ionic liquids-based processes have been demonstrated not only in the convenient and efficient synthesis of 1,2,3-triazolyl compounds but also in the discovery of a new reaction for the chemical post-modification of free peptides.

DOI10.1039/c8gc03119c
Language英语
WOS KeywordRegioselective Synthesis ; Click Chemistry ; Identification ; Efficient ; Ligands ; Carbon
Funding ProjectNational Natural Science Foundation of China[21373079] ; National Natural Science Foundation of China[21778015] ; Program for Science & Technology Innovation Talents in Universities of Henan Province[14HASTIT015] ; 111 Project[D17007]
WOS Research AreaChemistry ; Science & Technology - Other Topics
WOS SubjectChemistry, Multidisciplinary ; Green & Sustainable Science & Technology
Funding OrganizationNational Natural Science Foundation of China ; Program for Science & Technology Innovation Talents in Universities of Henan Province ; 111 Project
WOS IDWOS:000457596200011
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/27880
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Lingjun; Wang, Jianji
Affiliation1.Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn,Minist Educ,Key Lab Green Ch, Xinxiang 453007, Henan, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Anlian,Li, Lingjun,Zhang, Chi,et al. An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes[J]. GREEN CHEMISTRY,2019,21(2):307-313.
APA Zhu, Anlian.,Li, Lingjun.,Zhang, Chi.,Shen, Yutan.,Tang, Mingjie.,...&Wang, Jianji.(2019).An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes.GREEN CHEMISTRY,21(2),307-313.
MLA Zhu, Anlian,et al."An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes".GREEN CHEMISTRY 21.2(2019):307-313.
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