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CO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst
Zhao, Guo-Ying1; Mu, Ling-Ling1,2; Ullah, Latif1; Wang, Meng1; Li, Hong-Ping2; Guan, Xin-Xin2
2019-03-01
Source PublicationCANADIAN JOURNAL OF CHEMISTRY
ISSN0008-4042
Volume97Issue:3Pages:212-218
AbstractIn this study, pharmaceutically relevant quinazoline-2,4(1H, 3H)-diones were synthesized eco-efficiently by cycloaddition of CO2 and 2-aminobenzonitrile in water, catalyzed by melamine as a thermoregulated catalyst. Quinazoline-2,4(1H, 3H)-dione was produced selectively with 92% yield at 120 degrees C, 4.2 MPa, and automatically separated from the hot catalytic aqueous solution, which was reused directly for several runs until its activity decreased in an obvious manner. Then, the catalyst melamine was recrystallized from the spent aqueous solution via simple cooling and reused for another several catalytic runs. The efficient valorization of CO2 and the straightforward stepwise recovery of the products and catalyst were important to save energy and minimize process waste for the practical industrial production.
Keywordquinazoline-2 carbon dioxide water thermoregulated catalyst cycloaddition 4(1H 3H)-diones
DOI10.1139/cjc-2017-0705
Language英语
WOS KeywordCARBON-DIOXIDE ; EFFICIENT SYNTHESIS ; ROOM-TEMPERATURE ; IONIC LIQUIDS ; CONVERSION ; FIXATION
Funding ProjectNational Natural Science Foundation of China[51374193] ; National Natural Science Foundation of China[21676278] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201624]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Instrument Developing Project of the Chinese Academy of Sciences
WOS IDWOS:000459583500006
PublisherCANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28022
Collection中国科学院过程工程研究所
Corresponding AuthorZhao, Guo-Ying; Guan, Xin-Xin
Affiliation1.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, Key Lab Green Proc & Engn,Inst Proc Engn, Beijing 100190, Peoples R China
2.Zhengzhou Univ, Coll Chem & Mol Engn, 100 Sci Rd, Zhengzhou 450001, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Guo-Ying,Mu, Ling-Ling,Ullah, Latif,et al. CO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst[J]. CANADIAN JOURNAL OF CHEMISTRY,2019,97(3):212-218.
APA Zhao, Guo-Ying,Mu, Ling-Ling,Ullah, Latif,Wang, Meng,Li, Hong-Ping,&Guan, Xin-Xin.(2019).CO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst.CANADIAN JOURNAL OF CHEMISTRY,97(3),212-218.
MLA Zhao, Guo-Ying,et al."CO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst".CANADIAN JOURNAL OF CHEMISTRY 97.3(2019):212-218.
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