CAS OpenIR
Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging
Li, Shukun1; Liu, Yamei1; Xing, Ruirui1; Yan, Xuehai1,2
2019-02-15
Source PublicationCHEMBIOCHEM
ISSN1439-4227
Volume20Issue:4Pages:555-560
AbstractPeptide self-assembly, inspired by the naturally occurring fabrication principle, remains the most attractive in constructing fluorescent nanoagents towards bioimaging. However, the noncovalent interactions that drive peptide self-assembly are usually susceptible to the complex physiological environment; thus leading to disassembly and dysfunction of fluorescent nanoagents. Herein, a covalently crosslinked assembly strategy for fabrication of stable peptide-based nanoparticles with adjustable emission is introduced. In the process of cationic diphenylalanine peptide (H-Phe-Phe-NH2 center dot HCl) self-assembly, glutaraldehyde is used as a crosslinker and the resulting product of the Schiff base reaction can be fluorescent. More importantly, the emission wavelength can be readily tuned by controlling the covalent reaction time. It has been demonstrated that the nanoparticles are stable, even after intracellular uptake, and can be used for sustainable multicolor fluorescent imaging. The strategy with integrating peptide self-assembly and covalent crosslinking could be promising for the design and engineering of functional fluorescent nanoparticles with robust physiological stability and adjustable emission towards improved bioimaging applications.
Keywordfluorescence imaging agents nanoparticles peptides self-assembly
DOI10.1002/cbic.201800434
Language英语
WOS KeywordCONJUGATED POLYMER NANOPARTICLES ; SEMICONDUCTING POLYMER ; CONSTRUCTION ; NANOCARRIERS ; DELIVERY ; DESIGN ; PROBES ; DOTS ; TIME
Funding ProjectNational Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21473208] ; National Natural Science Foundation of China[201773248] ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005]
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal
Funding OrganizationNational Natural Science Foundation of China ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of the Frontier Sciences of the Chinese Academy of Sciences ; CAS President's International Fellowship Initiative
WOS IDWOS:000458825800016
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28030
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North Second St, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Shukun,Liu, Yamei,Xing, Ruirui,et al. Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging[J]. CHEMBIOCHEM,2019,20(4):555-560.
APA Li, Shukun,Liu, Yamei,Xing, Ruirui,&Yan, Xuehai.(2019).Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging.CHEMBIOCHEM,20(4),555-560.
MLA Li, Shukun,et al."Covalently Assembled Dipeptide Nanoparticles with Adjustable Fluorescence Emission for Multicolor Bioimaging".CHEMBIOCHEM 20.4(2019):555-560.
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