CAS OpenIR
Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers
Wang, Quan1; Zhang, Ruirui2,3; You, Guoxing1; Hu, Jilin1; Li, Penglong1; Wang, Ying1; Zhang, Jun1; Wu, Yan2; Zhao, Lian1; Zhou, Hong1
2018
Source PublicationARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN2169-1401
Volume46Pages:484-492
AbstractOxidative toxicity has impeded the development of haemoglobin-based oxygen carriers (HBOCs) by causing methaemoglobin (MetHb) formation and inducing oxidative stress. In our previous work, polydopamine-coated haemoglobin (Hb-PDA) nanoparticles have been designed and synthesized with the capacity to reduce oxidative toxicity. In this investigation, the mass ratio of dopamine (DA) to haemoglobin (Hb) and the pH value are found to be the primary factors that influence preparation of Hb-PDA nanoparticles. X-ray photoelectron spectroscopy showed that the catechol groups of DA play a crucial role in the modification of Hb surface. Hb-PDA nanoparticles were found to exhibit oxidative protection from hydrogen peroxide (H2O2) and the change of mitochondrial membrane potential showed that the Hb-PDA nanoparticles reduced H2O2-induced apoptosis. It is demonstrated that modification of PDA could maintain the oxygen-release capacity of Hb. These findings confirm that Hb-PDA nanoparticles possess restrained oxidative toxicity and preserve oxygen-release capacity.
KeywordPolydopamine haemoglobin surface modification oxygen carriers oxidative toxicity
DOI10.1080/21691401.2018.1459636
Language英语
WOS KeywordOXIDE SURFACES ; NANOPARTICLES ; BINDING ; BLOOD ; PERFORMANCE
Funding ProjectNational Natural Science Foundation of China[81700181] ; National Natural Science Foundation of China[81600148] ; National Natural Science Foundation of China[21705151] ; Beijing Natural Science Foundation[2174085]
WOS Research AreaBiotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS SubjectBiotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS IDWOS:000459181400047
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28036
Collection中国科学院过程工程研究所
Corresponding AuthorWu, Yan; Zhao, Lian; Zhou, Hong
Affiliation1.Acad Mil Med Sci, Inst Hlth Serv & Transfus Med, Beijing Key Lab Blood Safety & Supply Technol, Beijing, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Quan,Zhang, Ruirui,You, Guoxing,et al. Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:484-492.
APA Wang, Quan.,Zhang, Ruirui.,You, Guoxing.,Hu, Jilin.,Li, Penglong.,...&Zhou, Hong.(2018).Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,484-492.
MLA Wang, Quan,et al."Influence of polydopamine-mediated surface modification on oxygen-release capacity of haemoglobin-based oxygen carriers".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):484-492.
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