CAS OpenIR
Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates
Feng, Lu1,2; Ren, Peng1,2; Hao, Linna1,3; Dong, Qianqian1,3; Li, Jieling1; Jian, Honglei1; Wang, Meiyue1,2; Li, Xin1,2; Wang, Anhe1; Bai, Shuo1
2019-07-20
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume573Pages:22-29
Abstract

Short peptide cages have great potential applications in drug encapsulation and release because of excellent biocompatibility, biodegradability and multi-functionality originated from their abundant sequences. However, constructing short peptide cages are still a challenge, which is caused by the rapid kinetic and unlimited self-assembly behavior of short peptide in a macroscopical media. Herein, we developed smart procedures to produce short peptide cages, in which porous CaCO3 microparticles were used as enzyme (thermolysin) carriers and applied as catalyzers to promote the condensation reaction of Fmoc-Y and L-NH2 in confined space of water/n-hexane emulsion which limited the self-assembly behavior of Fmoc-YL-NH2 and allowed the peptide to just selfassemble on CaCO3 surface. Intact short peptide cages would be produced after the removing the templates.

KeywordCaco3 Microparticles Short Peptide Cages Self-assembly Confined Space
DOI10.1016/j.colsurfa.2019.04.048
Language英语
WOS KeywordRational Design ; In-vitro ; Therapy ; Nanoparticles ; Hydrogels ; Transition ; Emulsions ; Nanocages ; Vesicles ; Release
Funding ProjectNational Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21,703,253]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000468418300004
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28135
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Anhe; Bai, Shuo
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Peoples R China
Recommended Citation
GB/T 7714
Feng, Lu,Ren, Peng,Hao, Linna,et al. Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,573:22-29.
APA Feng, Lu.,Ren, Peng.,Hao, Linna.,Dong, Qianqian.,Li, Jieling.,...&Bai, Shuo.(2019).Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,573,22-29.
MLA Feng, Lu,et al."Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 573(2019):22-29.
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