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A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions
Yang, Mengyao1,2; Xing, Ruirui1; Shen, Guizhi1; Yuan, Chengqian1; Yan, Xuehai1,2
2019-07-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume572Pages:259-265
Abstract

Peptide-based supramolecular hydrogels as functional soft materials hold great promising for biomedical applications. However, much effort has been devoted to the finding and development of linear peptide hydrogelators and related hydrogel materials. Usually, linear peptide hydrogels are subject to the environmental variations and suffer from rapid enzymatic degradation in physiological conditions, limiting their more broad range of applications. Herein, we discover that a cyclic dipeptide (Cyclo-(Leu-Phe), CLF) can serve as a versatile hydrogelator for formation of supramolecular hydrogels at various physiological and harsh environments including the presence of salts, proteins and enzymes as well as acidic and basic aqueous solutions. Importantly, the CLF hydrogels show robust stability and excellent rheological properties at the various conditions, which are attributable to the rigid molecular structure of cyclic dipeptides and their strong 3-dimentional intermolecular hydrogen bonding networks. Hence, cyclic dipeptides provide a new alternative for development of peptide-based hydrogel materials with properties and functions more adapted for the complex and harsh environments.

KeywordCyclic Dipeptide Self-assembly Hydrogel Stability Rheology
DOI10.1016/j.colsurfa.2019.04.020
Language英语
WOS KeywordMolecular-weight Gelators ; Bonding Network ; Peptide ; Transformation ; Transition ; Tough ; Acid
Funding ProjectNational Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000466612900028
PublisherELSEVIER SCIENCE BV
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28145
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Mengyao,Xing, Ruirui,Shen, Guizhi,et al. A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,572:259-265.
APA Yang, Mengyao,Xing, Ruirui,Shen, Guizhi,Yuan, Chengqian,&Yan, Xuehai.(2019).A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,572,259-265.
MLA Yang, Mengyao,et al."A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 572(2019):259-265.
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