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| Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo | |
| Li, Wenfang1; Hu, Xueyan1; Wang, Shuping2,3; Xing, Yan4; Wang, Hai1; Nie, Yi5,6; Liu, Tianqing1; Song, Kedong1 | |
| 2019-06-01 | |
| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| ISSN | 0141-8130 |
| Volume | 130Pages:166-176 |
| Abstract | Potential anti-cancer drugs are frequently of low efficacy in clinics due to the lack of predictive models or the insufficient employment of existing preclinical test systems. Three-dimensional (3D) in vitro engineered tumor models can better predict the efficacy of novel drugs by reproducing the in vivo tumor microenvironment. In this study, three sources of scaffolds (decellularized lung scaffold, chitosan/gelatin scaffold, and poly-L-lactic acid scaffold) incorporated with breast cancer cells (MCF-7, 4T1) were bioengineered as a platform to study in vitro solid tumor development The good biocompatibility of three scaffolds favored cell growth and proliferation. Cells in 3D scaffolds were less sensitive to chemotherapy and exhibited characteristics of higher malignancy compared to their 2D counterparts. The expression of breast cancer biomarkers in MCF-7 cells markedly up-regulated in 3D scaffolds in comparison with those in 2D cultures. Cells grown in 3D scaffolds were found to be more tumorigenic and angiogenic in BABL/c mice xenografts than cells grown from monolayers. The results demonstrate that 3D engineered tumor model can better mimic in vivo tumor and can serve as a more appropriate platform for the study and screening of novel cancer therapeutics. (C) 2019 Published by Elsevier B.V. |
| Keyword | 3D tumor model Decellularized lung matrix Chitosan/gelatin Poly-L-lactic acid Cell response Drug screening |
| DOI | 10.1016/j.ijbiomac.2019.02.136 |
| Language | 英语 |
| WOS Keyword | SCAFFOLDS ; CANCER ; FABRICATION ; CELLS ; DRUG |
| Funding Project | National Natural Science Foundation of China[31670978/31370991/21676041] ; Fok Ying Tung Education Foundation[132027] ; State Key Laboratory of Fine Chemicals[KF1111] ; Natural Science Foundation of Liaoning Province[20180510028] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| Funding Organization | National Natural Science Foundation of China ; Fok Ying Tung Education Foundation ; State Key Laboratory of Fine Chemicals ; Natural Science Foundation of Liaoning Province |
| WOS ID | WOS:000466253000018 |
| Publisher | ELSEVIER SCIENCE BV |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/28177 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Song, Kedong |
| Affiliation | 1.Dalian Univ Technol, State Key Lab Fine Chem, Dalian R&D Ctr Stem Cell & Tissue Engn, Dalian 116024, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Regenerat Med Ctr, Dalian 116024, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Stem Cell Clin Res Ctr, Dalian 116024, Peoples R China 4.Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China 5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China 6.Chinese Acad Sci, Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Wenfang,Hu, Xueyan,Wang, Shuping,et al. Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,130:166-176. |
| APA | Li, Wenfang.,Hu, Xueyan.,Wang, Shuping.,Xing, Yan.,Wang, Hai.,...&Song, Kedong.(2019).Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,130,166-176. |
| MLA | Li, Wenfang,et al."Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 130(2019):166-176. |
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