CAS OpenIR
Engineering Magnetosomes for High-Performance Cancer Vaccination
Li, Feng1; Nie, Weidong1; Zhang, Fan1; Lu, Guihong1; Lv, Chengliang1; Lv, Yanlin2; Bao, Weier2,3; Zhang, Lijun2,3; Wang, Shuang2; Gao, Xiaoyong2; Wei, Wei2,3; Xie, Hai-Yan1
2019-05-22
Source PublicationACS CENTRAL SCIENCE
ISSN2374-7943
Volume5Issue:5Pages:796-807
AbstractA novel cancer vaccine is developed by using Fe3O4 magnetic nanoclusters (MNCs) as the core and cancer cell membranes decorated with anti-CD205 as the cloak. Because of the superparamagnetism and magnetization of MNCs, it is first achieved for the magnetic retention of vaccine in the lymph nodes with a magnetic resonance imaging (MRI) guide, which opened the time window for antigen uptake by dendritic cells (DCs). Meanwhile, the camouflaged cancer cell membranes serve as a reservoir of various antigens, enabling subsequent multiantigenic response. Additionally, the decorated anti-CD205 direct more vaccine into CD8(+) DCs, facilitating the major histocompatibility complex (MHC) I cross-presentation. These unique advantages together lead to a great proliferation of T cells with superior clonal diversity and cytotoxic activity. As a result, potent prophylactic and therapeutic effects with few abnormalities are observed on five different tumor models. Therefore, such a cancer-derived magnetosome with the integration of various recent nanotechnologies successfully demonstrates its promise for safe and high-performance cancer vaccination.
DOI10.1021/acscentsci.9b00060
Language英语
WOS KeywordLIPID-A MPLA ; SYNTHETIC VACCINES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; ADJUVANT ; DNA ; CHALLENGES ; INFLUENZA ; NODE
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000468624100012
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28189
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Xie, Hai-Yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Feng,Nie, Weidong,Zhang, Fan,et al. Engineering Magnetosomes for High-Performance Cancer Vaccination[J]. ACS CENTRAL SCIENCE,2019,5(5):796-807.
APA Li, Feng.,Nie, Weidong.,Zhang, Fan.,Lu, Guihong.,Lv, Chengliang.,...&Xie, Hai-Yan.(2019).Engineering Magnetosomes for High-Performance Cancer Vaccination.ACS CENTRAL SCIENCE,5(5),796-807.
MLA Li, Feng,et al."Engineering Magnetosomes for High-Performance Cancer Vaccination".ACS CENTRAL SCIENCE 5.5(2019):796-807.
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