CAS OpenIR
Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
Lu, Guihong1; Lv, Chengliang1; Bao, Weier2; Li, Feng1; Zhang, Fan1; Zhang, Lijun2; Wang, Shuang2; Gao, Xiaoyong2; Zhao, Dongxu1; Wei, Wei2; Xie, Hai-yan1
2019-05-14
Source PublicationCHEMICAL SCIENCE
ISSN2041-6520
Volume10Issue:18Pages:4847-4853
AbstractAlthough the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (similar to 55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/ photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy.
DOI10.1039/c9sc00324j
Language英语
WOS KeywordCLEARANCE ABC PHENOMENON ; OXIDE NANOPARTICLES ; BLACK PHOSPHORUS ; THERAPY ; SIZE
Funding ProjectNational Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001] ; National Key R&D Program of China[2017YFA0207900]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; National Science and Technology Major Project ; National Key R&D Program of China
WOS IDWOS:000468818700011
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28203
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Xie, Hai-yan
Affiliation1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lu, Guihong,Lv, Chengliang,Bao, Weier,et al. Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics[J]. CHEMICAL SCIENCE,2019,10(18):4847-4853.
APA Lu, Guihong.,Lv, Chengliang.,Bao, Weier.,Li, Feng.,Zhang, Fan.,...&Xie, Hai-yan.(2019).Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics.CHEMICAL SCIENCE,10(18),4847-4853.
MLA Lu, Guihong,et al."Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics".CHEMICAL SCIENCE 10.18(2019):4847-4853.
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