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Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics | |
Lu, Guihong1; Lv, Chengliang1; Bao, Weier2; Li, Feng1; Zhang, Fan1; Zhang, Lijun2; Wang, Shuang2; Gao, Xiaoyong2; Zhao, Dongxu1; Wei, Wei2; Xie, Hai-yan1 | |
2019-05-14 | |
Source Publication | CHEMICAL SCIENCE
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ISSN | 2041-6520 |
Volume | 10Issue:18Pages:4847-4853 |
Abstract | Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (similar to 55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/ photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy. |
DOI | 10.1039/c9sc00324j |
Language | 英语 |
WOS Keyword | Clearance Abc Phenomenon ; Oxide Nanoparticles ; Black Phosphorus ; Therapy ; Size |
Funding Project | National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001] ; National Key R&D Program of China[2017YFA0207900] |
WOS Research Area | Chemistry |
WOS Subject | Chemistry, Multidisciplinary |
Funding Organization | National Natural Science Foundation of China ; National Science and Technology Major Project ; National Key R&D Program of China |
WOS ID | WOS:000468818700011 |
Publisher | ROYAL SOC CHEMISTRY |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ipe.ac.cn/handle/122111/28203 |
Collection | 中国科学院过程工程研究所 |
Corresponding Author | Wei, Wei; Xie, Hai-yan |
Affiliation | 1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China |
Recommended Citation GB/T 7714 | Lu, Guihong,Lv, Chengliang,Bao, Weier,et al. Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics[J]. CHEMICAL SCIENCE,2019,10(18):4847-4853. |
APA | Lu, Guihong.,Lv, Chengliang.,Bao, Weier.,Li, Feng.,Zhang, Fan.,...&Xie, Hai-yan.(2019).Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics.CHEMICAL SCIENCE,10(18),4847-4853. |
MLA | Lu, Guihong,et al."Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics".CHEMICAL SCIENCE 10.18(2019):4847-4853. |
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File Name/Size | DocType | Version | Access | License | ||
Antimonene with two-(3234KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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