CAS OpenIR
Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics
Xing, Ruirui1; Zou, Qianli1; Yuan, Chengqian1; Zhao, Luyang1; Chang, Rui1,2; Yan, Xuehai1,2,3
2019-04-19
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume31Issue:16Pages:8
Abstract

Photothermal nanomaterials that integrate multimodal imaging and therapeutic functions provide promising opportunities for noninvasive and targeted diagnosis and treatment in precision medicine. However, the clinical translation of existing photothermal nanoagents is severely hindered by their unclear physiological metabolism, which makes them a strong concern for biosafety. Here, the utilization of biliverdin (BV), an endogenic near-infrared (NIR)-absorbing pigment with well-studied metabolic pathways, to develop photothermal nanoagents with the aim of providing efficient and metabolizable candidates for tumor diagnosis and therapy, is demonstrated. It is shown that BV nanoagents with intense NIR absorption, long-term photostability and colloidal stability, and high photothermal conversion efficiency can be readily constructed by the supramolecular multicomponent self-assembly of BV, metal-binding short peptides, and metal ions through the reciprocity and synergy of coordination and multiple noncovalent interactions. In vivo data reveal that the BV nanoagents selectively accumulate in tumors, locally elevate tumor temperature under mild NIR irradiation, and consequently induce efficient photothermal tumor ablation with promising biocompatibility. Furthermore, the BV nanoagents can serve as a multimodal contrast for tumor visualization through both photoacoustic and magnetic resonance imaging. BV has no biosafety concerns, and thereby offers a great potential in precision medicine by integrating multiple theranostic functions.

KeywordBiliverdin Biosafety Endogenic Pigment Photothermal Therapy Self-assembly
DOI10.1002/adma.201900822
Language英语
WOS KeywordContrast Agents ; Fluorescent Protein ; Nanoparticles ; Bilirubin ; Photosensitizers ; Tomography ; Expression ; Stability ; Peptides
Funding ProjectNational Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000468005400031
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/28233
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xing, Ruirui,Zou, Qianli,Yuan, Chengqian,et al. Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics[J]. ADVANCED MATERIALS,2019,31(16):8.
APA Xing, Ruirui,Zou, Qianli,Yuan, Chengqian,Zhao, Luyang,Chang, Rui,&Yan, Xuehai.(2019).Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics.ADVANCED MATERIALS,31(16),8.
MLA Xing, Ruirui,et al."Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics".ADVANCED MATERIALS 31.16(2019):8.
Files in This Item:
File Name/Size DocType Version Access License
Self-Assembling Endo(5279KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xing, Ruirui]'s Articles
[Zou, Qianli]'s Articles
[Yuan, Chengqian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xing, Ruirui]'s Articles
[Zou, Qianli]'s Articles
[Yuan, Chengqian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xing, Ruirui]'s Articles
[Zou, Qianli]'s Articles
[Yuan, Chengqian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.